[Di Toro, M.
; Greco, V.
; Colonna, M.
; Plumari, S.] Ist Nazl Fis Nucl, Lab Nazl Sud, I-95123 Catania, Italy
; [Di Toro, M.
; Greco, V.
; Plumari, S.] Univ Catania, Dept Phys & Astron, I-95124 Catania, Italy
; [Liu, B.] Chinese Acad Sci, IHEP, Beijing, Peoples R China
; [Liu, B.] Chinese Acad Sci, Theoret Phys Ctr Sci Facil, Beijing 100049, Peoples R China
; [Baran, V.] Univ Bucharest, Fac Phys, Bucharest, Romania
The phase transition of hadronic to quark matter at high baryon and isospin density is analyzed. Relativistic mean-field models are used to describe hadronic matter, and the MIT bag model is adopted for quark matter. The boundaries of the mixed phase and the related critical points for symmetric and asymmetric matter are obtained. Due to the different symmetry term in the two phases, isospin effects appear to be rather significant. With increasing isospin asymmetry the binodal transition line of the (T,rho(B)) diagram is lowered to a region accessible through heavy-ion collisions in the energy range of the new planned facilities (e.g., the FAIR/NICA projects). Some observable effects are suggested, in particular an isospin distillation mechanism with a more isospin asymmetric quark phase, to be seen in charged meson yield ratios, and an onset of quark number scaling of the meson-baryon elliptic flows. The presented isospin effects on the mixed phase appear to be robust with respect to even large variations of the poorly known symmetry term at high baryon density in the hadron phase. The dependence of the results on a suitable treatment of isospin contributions in effective QCD Lagrangian approaches, at the level of explicit isovector parts and/or quark condensates, is discussed.