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EXAFS study on the local atomic structures around iron in glycosylated haemoglobin
Wu ZH(吴忠华); Guo L(郭林); Wu, ZH; Benfield, RE; Wang, YS; Guo, L; Tan, MG; Zhang, HD; Ge, YX; Grandjean, D
2001
发表期刊PHYSICS IN MEDICINE AND BIOLOGY
卷号46期号:3页码:N71-N77
通讯作者Chinese Acad Sci, Inst High Energy Phys, BSRL, Beijing 100039, Peoples R China ; Univ Kent, Ctr Mat Res, Sch Phys Sci, Canterbury CT2 7NR, Kent, England ; Chinese Acad Sci, Shanghai Inst Nucl Res, Shanghai 201800, Peoples R China ; First Peoples Hosp Shanghai, Shanghai 200080, Peoples R China
文章类型Article
摘要Samples with 5.1%, 9.8% and 15.3% HbA1c were extracted from normal subjects and patients with slight and serious diabetes respectively. Extended x-ray absorption fine structure spectra of Fe K absorption were collected at the EXAFS experimental station of the Beijing Synchrotron Radiation Facility. The step-by-step fluorescent mode was employed with a count time of 10 s per point. Several independent scans were averaged to eliminate the statistical noise. Reference backscattering amplitudes and phaseshifts were calculated using the curve wave theory (FEFF code) of EXAFS. Apart from the nitrogen neighbours around the central iron atom, oxygen neighbours are also found. The Fe-N bond length increases by about 0.02 Angstrom for the sample with 15.3% HbA1c compared with the others, but the Fe-O bond length is almost unchanged. With increasing of HbA1c concentration, the content of Hb increases and the content of HbO(2) decreases. This demonstrates that the glycosylation of haemoglobin will decrease its ability to carry oxygen.
学科领域Engineering; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Engineering ; Radiology, Nuclear Medicine & Medical Imaging ; Engineering ; Radiology, Nuclear Medicine & Medical Imaging
DOI10.1088/0031-9155/46/3/403
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语种英语
研究领域[WOS]Engineering ; Radiology, Nuclear Medicine & Medical Imaging ; Engineering ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Engineering, Biomedical ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000167520400024
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被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/240315
专题多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Wu ZH,Guo L,Wu, ZH,et al. EXAFS study on the local atomic structures around iron in glycosylated haemoglobin[J]. PHYSICS IN MEDICINE AND BIOLOGY,2001,46(3):N71-N77.
APA 吴忠华.,郭林.,Wu, ZH.,Benfield, RE.,Wang, YS.,...&Grandjean, D.(2001).EXAFS study on the local atomic structures around iron in glycosylated haemoglobin.PHYSICS IN MEDICINE AND BIOLOGY,46(3),N71-N77.
MLA 吴忠华,et al."EXAFS study on the local atomic structures around iron in glycosylated haemoglobin".PHYSICS IN MEDICINE AND BIOLOGY 46.3(2001):N71-N77.
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