IHEP OpenIR  > 院士  > 期刊论文
Age-Related Differences in Pulmonary and Cardiovascular Responses to SiO(2) Nanoparticle Inhalation: Nanotoxicity Has Susceptible Population
Chen Z(陈真); Meng H(孟幻); Xing GM(邢更妹); Yuan H(袁慧); Zhao F(赵峰); Liu R(刘茹); Chang XL(常雪灵); Gao XY(高学云); Ye C(叶昶); Chai ZF(柴之芳); Zhao YL(赵宇亮); Chen, Z; Meng, H; Xing, GM; Yuan, H; Zhao, F; Liu, R; Chang, XL; Gao, XY; Wang, TC; Jia, G; Ye, C; Chai, ZF; Zhao, YL
刊名ENVIRONMENTAL SCIENCE & TECHNOLOGY
2008
卷号42期号:23页码:8985-8992
学科分类Engineering; Environmental Sciences & Ecology
DOI10.1021/es800975u
通讯作者[Chen, Zhen ; Meng, Huan ; Xing, Gengmei ; Yuan, Hui ; Zhao, Feng ; Liu, Ru ; Chang, Xuelin ; Gao, Xueyun ; Ye, Chang ; Chai, Zhifang ; Zhao, Yuliang] Chinese Acad Sci, Lab Bioenvironm Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Chen, Zhen ; Meng, Huan ; Xing, Gengmei ; Yuan, Hui ; Zhao, Feng ; Liu, Ru ; Chang, Xuelin ; Gao, Xueyun ; Ye, Chang ; Chai, Zhifang ; Zhao, Yuliang] Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China ; [Jia, Guang] Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China ; [Wang, Tiancheng] Peking Univ, Hosp 3, Beijing 100083, Peoples R China ; [Chen, Zhen ; Meng, Huan ; Liu, Ru ; Gao, Xueyun ; Zhao, Yuliang] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
文章类型Article
英文摘要Epidemiologic studies have revealed that pollution by ambient particulates is associated with respiratory and cardiovascular diseases, particularly in older people. Toxicologic sensitivity of nanoparticles in different ages was investigated for the first time to demonstrate and explain an age-related difference in response to manufactured nanoparticles. Young, adult, and old rats physiologically inhaled air containing aerosol of manufactured SiO(2) nanoparticles (24.1 mg/m(3); 40 min/day) for four weeks. Changes in serum biomarkers, hemorheologic, pulmonary inflammation, heart injury, and pathology in rats of different ages and their corresponding controls were compared. Inhalation of SiO(2) nanoparticles under identical conditions caused pulmonary and cardiovascular alterations in old rats, yet less change in young and adult rats, including pulmonary inflammation, myocardial ischernic damage, atrio-ventricular blockage, and increase in fibrinogen concentration and blood viscosity. Old individuals were more sensitive to nanoparticle exposure than the young and adult rats. The risk of causing pulmonary damages was: old > young > adult. The risk of cardiovascular disorder was observed only in old age. Our results suggest that different ages may require different biomarkers for identifying pulmonary toxicity during inhalation of nanoparticles.
类目[WOS]Engineering, Environmental ; Environmental Sciences
研究领域[WOS]Engineering ; Environmental Sciences & Ecology
原文出处查看原文
语种英语
WOS记录号WOS:000261307200063
引用统计
被引频次:68[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/240154
专题院士_期刊论文
中国科学院高能物理研究所_加速器中心
中国科学院高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714
Chen Z,Meng H,Xing GM,et al. Age-Related Differences in Pulmonary and Cardiovascular Responses to SiO(2) Nanoparticle Inhalation: Nanotoxicity Has Susceptible Population[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2008,42(23):8985-8992.
APA 陈真.,孟幻.,邢更妹.,袁慧.,赵峰.,...&Zhao, YL.(2008).Age-Related Differences in Pulmonary and Cardiovascular Responses to SiO(2) Nanoparticle Inhalation: Nanotoxicity Has Susceptible Population.ENVIRONMENTAL SCIENCE & TECHNOLOGY,42(23),8985-8992.
MLA 陈真,et al."Age-Related Differences in Pulmonary and Cardiovascular Responses to SiO(2) Nanoparticle Inhalation: Nanotoxicity Has Susceptible Population".ENVIRONMENTAL SCIENCE & TECHNOLOGY 42.23(2008):8985-8992.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
7723.pdf(6925KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[陈真]的文章
[孟幻]的文章
[邢更妹]的文章
百度学术
百度学术中相似的文章
[陈真]的文章
[孟幻]的文章
[邢更妹]的文章
必应学术
必应学术中相似的文章
[陈真]的文章
[孟幻]的文章
[邢更妹]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 7723.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。