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Effects of Copper Nanoparticles on the Development of Zebrafish Embryos
Bai W(白伟); Zhang ZY(张智勇); He X(何潇); Ma YH(马宇辉); Liu NQ(刘年庆); Chai ZF(柴之芳); Bai, W; Tian, WJ; Zhang, ZY; He, XA; Ma, YH; Liu, NQ; Chai, ZF
Corresponding Author[Bai, Wei ; Zhang, Zhiyong ; He, Xiao ; Ma, Yuhui ; Liu, Nianqing ; Chai, Zhifang] Chinese Acad Sci, CAS Key Lab Biol Effects Nanomat & Nanosaf, Beijing 100049, Peoples R China ; [Bai, Wei ; Zhang, Zhiyong ; He, Xiao ; Ma, Yuhui ; Liu, Nianqing ; Chai, Zhifang] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [Tian, Wenjing] Qingdao Univ Sci & Technol, Qingdao 266061, Peoples R China
SubtypeArticle; Proceedings Paper
AbstractThe environmental behavior and the potential toxicity of copper nanoparticles (nano-Cu) in water are major concerns for assessing their environmental safety. The present study was undertaken to characterize the properties of nano-Cu in E3 medium, such as size changes, solubility, zeta-potential and pH, and to test the toxicity of nano-Cu suspension to zebrafish embryos. Dynamic light scattering and solubility experiments showed that three components coexisted in the nano-Cu exposure system, including small nano-Cu aggregates still suspended in E3 medium, large nano-Cu aggregates deposited on the container bottom and dissolved copper species (Cu((dis))). Both the zeta-potential of nano-Cu particles in E3 medium and the pH of the nano-Cu suspension showed no change during a 24 hour period. It is found that nano-Cu retarded the hatching of zebrafish embryos and caused morphological malformation of the larvae, and high concentrations (>0.1 mg/L) of nano-Cu even killed the gastrula-stage zebrafish embryos. Cu(2+) ions were used to study the toxicity caused by nano-Cu dissolution. The embryo toxicity of nano-Cu at 0.01 and 0.05 mg/L showed no significant difference from Cu(2+) at the corresponding concentrations (0.006 and 0.03 mg/L), but 0.1 mg/L nano-Cu had a greater toxicity than 0.06 mg/L Cu(2+).
KeywordZebrafish Embryos Copper Nanoparticle Toxicity Solubility Size
Subject AreaChemistry; Science & Technology - Other Topics; Materials Science; Physics
Indexed BySCI
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000283621400108
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Document Type期刊论文
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Bai W,Zhang ZY,He X,et al. Effects of Copper Nanoparticles on the Development of Zebrafish Embryos[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(12):8670-8676.
APA 白伟.,张智勇.,何潇.,马宇辉.,刘年庆.,...&Chai, ZF.(2010).Effects of Copper Nanoparticles on the Development of Zebrafish Embryos.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,10(12),8670-8676.
MLA 白伟,et al."Effects of Copper Nanoparticles on the Development of Zebrafish Embryos".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 10.12(2010):8670-8676.
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