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Modulation of Oxidative Stress by Functionalized Fullerene Materials in the Lung Tissues of Female C57/BL Mice with a Metastatic Lewis Lung Carcinoma
Jiao F(焦芳); Qiu Y(邱莹); Zhou GQ(周国强); Liu Y(刘颖); Li W(李炜); Ge CC(葛翠翠); Li YF(李玉锋); Li B(李柏); Gao YX(高愈希); Chen CY(陈春英); Jiao, F; Qu, Y; Zhou, GQ; Liu, Y; Li, W; Ge, CC; Li, YF; Hu, W; Li, B; Gao, YX; Chen, CY
2010
发表期刊JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷号10期号:12页码:8632-8637
通讯作者[Hu, Wei] Shandong Univ Technol, Zibo 255049, Peoples R China ; [Jiao, Fang ; Qu, Ying ; Zhou, Guoqiang ; Liu, Ying ; Li, Wei ; Ge, Cuicui ; Li, Yufeng ; Li, Bai ; Gao, Yuxi ; Chen, Chunying] NCNST, Beijing 100190, Peoples R China ; [Jiao, Fang ; Qu, Ying ; Zhou, Guoqiang ; Liu, Ying ; Li, Wei ; Ge, Cuicui ; Li, Yufeng ; Li, Bai ; Gao, Yuxi ; Chen, Chunying] Chinese Acad Sci, IHEP, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [Jiao, Fang ; Qu, Ying ; Zhou, Guoqiang ; Liu, Ying ; Li, Wei ; Ge, Cuicui ; Li, Yufeng ; Li, Bai ; Gao, Yuxi ; Chen, Chunying] Chinese Acad Sci, CAS Key Lab Biol Effects Nanomat & Nanosafety, NCNST, IHEP, Beijing 100049, Peoples R China
文章类型Article; Proceedings Paper
摘要Oxidative stress is considered to be one of the important mechanisms involved in carcinogenesis. To investigate the effect of [Gd@C-82(OH)(22)](n) and [C-60(OH)(20)](n) nanoparticles on the oxidative stress, in the tumor-bearing mice, several antioxidative enzymes and antioxidants were tested for mice with or without tumor inoculation. Transplanted tumors were grown in mice by subcutaneous inoculation of a metastatic Lewis lung carcinoma in female C57/BL mice. More importantly, the tumor cells can metastasize into the normal lung tissues gradually. Therefore, in present paper, the activities of copper-zinc superoxide dismutase (CuZn-SOD), glutathione peroxidase (GSH-Px), glutathione S-transferase (GST), as well as the levels of reduced glutathione (GSH) and malondialdehyde (MDA) in the tumor-invaded lung tissues of the tumor-bearing mice were compared to the nomal lung tissues of normal mice. After treatment with nanoparticles, the activities of GSH-Px and GST and other parameters related to the oxidative stress were downregulated and tended closely to the normal levels. Pulmonary histopathological results also showed that two different types of water-soluble fullerenes can prevent lungs from inflammatory lesion and tumor invasion. These findings indicate two different types of water-soluble fullerenes materials can downregulate the oxidative stress status by scavenging excessive free radicals and inhibiting the lipid peroxidation in tumor-bearing mice, which can partly explain their protective roles on the pulmonary oxidative-damage induced by the tumor metastasis to lung tissues.
关键词[Gd@C-82(OH)(22)](n) Nanoparticles [C-60(OH)(20)](n) Nanoparticles Oxidative Stress
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics ; Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
DOI10.1166/jnn.2010.2489
URL查看原文
语种英语
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics ; Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号WOS:000283621400103
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/240148
专题多学科研究中心
实验物理中心
加速器中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Jiao F,Qiu Y,Zhou GQ,et al. Modulation of Oxidative Stress by Functionalized Fullerene Materials in the Lung Tissues of Female C57/BL Mice with a Metastatic Lewis Lung Carcinoma[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(12):8632-8637.
APA 焦芳.,邱莹.,周国强.,刘颖.,李炜.,...&Chen, CY.(2010).Modulation of Oxidative Stress by Functionalized Fullerene Materials in the Lung Tissues of Female C57/BL Mice with a Metastatic Lewis Lung Carcinoma.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,10(12),8632-8637.
MLA 焦芳,et al."Modulation of Oxidative Stress by Functionalized Fullerene Materials in the Lung Tissues of Female C57/BL Mice with a Metastatic Lewis Lung Carcinoma".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 10.12(2010):8632-8637.
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