Controlling Assembly of Paired Gold Clusters within Apoferritin Nanoreactor for in Vivo Kidney Targeting and Biomedical Imaging
Sun, CJ; Yang, H; Yuan, Y; Tian, X; Wang, LM; Guo, Y; Xu, L; Lei, JL; Gao, N; Anderson, GJ; Liang, XJ; Chen, CY; Zhao, YL; Nie, GJ; Zhao YL(赵宇亮)
刊名JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2011
卷号133期号:22页码:8617-8624
学科分类Chemistry
DOI10.1021/ja200746p
通讯作者[Sun, Cuiji ; Guo, Yi ; Xu, Li] Jilin Univ, Minist Educ, Key Lab Mol Enzymol & Engn, Changchun 130023, Peoples R China ; [Sun, Cuiji ; Yang, Hui ; Tian, Xin ; Wang, Liming ; Liang, Xing-Jie ; Chen, Chunying ; Zhao, Yuliang ; Nie, Guangjun] Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China ; [Yuan, Yi ; Lei, Jianlin ; Gao, Ning] Tsinghua Univ, Sch Life Sci, Struct Biol Ctr, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China ; [Anderson, Gregory J.] Royal Brisbane Hosp, Queensland Inst Med Res, Iron Metab Lab, Brisbane, Qld 4029, Australia ; [Zhao, Yuliang] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing, Peoples R China
文章类型Article
英文摘要Functional nanostructures with high biocompatibility and stability, low toxicity, and specificity of targeting to desired organs or cells are of great interest in nanobiology and medicine. However, the challenge is to integrate all of these desired features into a single nanobiostructure, which can be applied to biomedical applications and eventually in clinical settings. In this context, we designed a strategy to assemble two gold nanoclusters at the ferroxidase active sites of ferritin heavy chain. Our studies showed that the resulting nanostructures (Au-Ft) retain not only the intrinsic fluorescence properties of noble metal, but gain enhanced intensity, show a red-shift, and exhibit tunable emissions due to the coupling interaction between the paired Au clusters. Furthermore, Au-Ft possessed the well-defined nanostructure of native ferritin, showed organ-specific targeting ability, high biocompatibility, and low cytotoxicity. The current study demonstrates that an integrated multimodal assembly strategy is able to generate stable and effective biomolecule-noble metal complexes of controllable size and with desirable fluorescence emission characteristics. Such agents are ideal for targeted in vitro and in vivo imaging. These results thus open new opportunities for biomolecule-guided nanostructure assembly with great potential for biomedical applications.
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
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语种英语
WOS记录号WOS:000291414400049
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文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/240146
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
作者单位中国科学院高能物理研究所
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Sun, CJ,Yang, H,Yuan, Y,et al. Controlling Assembly of Paired Gold Clusters within Apoferritin Nanoreactor for in Vivo Kidney Targeting and Biomedical Imaging[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2011,133(22):8617-8624.
APA Sun, CJ.,Yang, H.,Yuan, Y.,Tian, X.,Wang, LM.,...&赵宇亮.(2011).Controlling Assembly of Paired Gold Clusters within Apoferritin Nanoreactor for in Vivo Kidney Targeting and Biomedical Imaging.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,133(22),8617-8624.
MLA Sun, CJ,et al."Controlling Assembly of Paired Gold Clusters within Apoferritin Nanoreactor for in Vivo Kidney Targeting and Biomedical Imaging".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 133.22(2011):8617-8624.
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