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Subcellular Distribution of Polyhydroxylated Metallofullerene Gd@C-82(OH)(22) in Different Tissues of Tumor-Bearing Mice
Zhou GQ(周国庆); Li YF(李玉锋); Liu Y(刘颖); Ge CC(葛翠翠); Li W(李炜); Sun BY(孙宝云); Li B(李柏); Gao YX(高愈希); Chen CY(陈春英); Zhou, GQ; Li, YF; Liu, Y; Ge, CC; Li, W; Sun, BY; Li, B; Gao, YX; Chen, CY
2010
发表期刊JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷号10期号:12页码:8597-8602
通讯作者[Sun, Baoyun] Chinese Acad Sci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100864, Peoples R China ; Chinese Acad Sci, Key Lab Nucl Analyt Tech, Inst High Energy Phys, Beijing 100864, Peoples R China
摘要Endohedral metallofullerenes have unique chemical and physical properties that are essential for biomedical applications. They can be used as a radiotracer in magnetic resonance and X-ray imaging (MRI and XRI). Polyhydroxylated metallofullerene Gd@C-82(OH)(x) has been studied as a new high efficient contrast agents for MRI and has also shown high efficiency for antitumor growth. Previous studies have shown that Gd@C-82(OH)(22) mainly accumulated in bone, pancreas, liver and kidney after intraperitoneal administration. However, whether the nanoparticles can enter into cells and the site of their potential action remains unclear. In this work, the distribution patterns of Gd@C-82(OH)(22) in subcellular compartments were studied using the techniques of differential centrifugation and ICP-MS analysis. The results indicate that the Gd@C-82(OH)(22) can enter into cells and the subcellular distribution patterns are significantly different from that of GdCl3. GdCl3 has much higher bioavailability for mice than Gd@C-82(OH)22. Therefore, the present data suggest that Gd@C-82(OH)(22) in living systems may be not decomposed to release free Gd3+ ion and may be metabolized as a pristine carbon cage.
文章类型Article; Proceedings Paper
关键词Subcellular Distribution Gd@C-82(OH)(22) Nanoparticle
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1166/jnn.2010.2486
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
URL查看原文
语种英语
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号WOS:000283621400098
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/240144
专题多学科研究中心
实验物理中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Zhou GQ,Li YF,Liu Y,et al. Subcellular Distribution of Polyhydroxylated Metallofullerene Gd@C-82(OH)(22) in Different Tissues of Tumor-Bearing Mice[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(12):8597-8602.
APA 周国庆.,李玉锋.,刘颖.,葛翠翠.,李炜.,...&Chen, CY.(2010).Subcellular Distribution of Polyhydroxylated Metallofullerene Gd@C-82(OH)(22) in Different Tissues of Tumor-Bearing Mice.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,10(12),8597-8602.
MLA 周国庆,et al."Subcellular Distribution of Polyhydroxylated Metallofullerene Gd@C-82(OH)(22) in Different Tissues of Tumor-Bearing Mice".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 10.12(2010):8597-8602.
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