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Oxidative Stress and Apoptosis Induced by Iron Oxide Nanoparticles in Cultured Human Umbilical Endothelial Cells
Zhu MT(朱墨桃); Wang Y(王云); Feng WY(丰伟悦); Wang B(汪冰); Wang M(王萌); Ou YH(欧阳宏); Chai ZF(柴之芳); Zhu, MT; Yun, W; Feng, WY; Bing, W; Meng, W; Hong, OY; Chai, ZF
2010
发表期刊JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷号10期号:12页码:8584-8590
通讯作者[Zhu, Mo-Tao ; Yun Wang ; Feng, Wei-Yue ; Bing Wang ; Meng Wang ; Hong Ouyang ; Chai, Zhi-Fang] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Zhu, Mo-Tao ; Yun Wang] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
摘要Recent epidemiologic researches indicate that exposure to ultrafine particles (nanoparticles) is an independent risk factor for several cardiovascular diseases. The induction of endothelial injuries is hypothesized to be an attractive mechanism involved in these cardiovascular diseases. To investigate this hypothesis, the widely used iron nanomaterials, ferric oxide (Fe(2)O(3)) and ferriferrous oxide (Fe(3)O(4)) nanoparticles were incubated with human umbilical endothelial cells (ECV304 cells) at different concentrations of 2, 20, 100 mu g/mL. The cell viability, the rate of apoptosis, the apoptotic nuclear morphology and the mitochondria membrane potential were measured to estimate the cell necrosis and apoptosis caused by the nanoparticle exposure. The stimulation of superoxide anion (O(2).(-)) and nitric oxide (NO) were examined to evaluate the stress responses of endothelial cells. Our results indicated that both the Fe(2)O(3) and Fe(3)O(4) nanoparticles could generate oxidative stress as well as the significant increase of nitric oxide in ECV304 cells. The loss of mitochondria membrane potential and the apoptotic chromatin condensation in the nucleus were observed as the early signs of apoptosis. It is inferred the stress response might be an important mechanism involving in endothelial cells apoptosis and death, and these injuries in endothelial cells might play a key role in downstream cardiovascular diseases such as atheroscelerosis, hypertension and myocardial infarction (MI).
文章类型Article; Proceedings Paper
关键词Iron Oxide Nanoparticle Oxidative Stress Apoptosis Human Umbilical Endothelial Cells
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1166/jnn.2010.2488
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
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语种英语
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号WOS:000283621400096
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文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/240143
专题院士
加速器中心
多学科研究中心
作者单位中国科学院高能物理研究所
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Zhu MT,Wang Y,Feng WY,et al. Oxidative Stress and Apoptosis Induced by Iron Oxide Nanoparticles in Cultured Human Umbilical Endothelial Cells[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(12):8584-8590.
APA 朱墨桃.,王云.,丰伟悦.,汪冰.,王萌.,...&Chai, ZF.(2010).Oxidative Stress and Apoptosis Induced by Iron Oxide Nanoparticles in Cultured Human Umbilical Endothelial Cells.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,10(12),8584-8590.
MLA 朱墨桃,et al."Oxidative Stress and Apoptosis Induced by Iron Oxide Nanoparticles in Cultured Human Umbilical Endothelial Cells".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 10.12(2010):8584-8590.
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