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Transmembrane Delivery of Aggregated [Gd@C-82(OH)(22)](n) Nanoparticles
Zhang MY(张铭倚); Xing GM(邢更妹); Yuan H(袁慧); Chang XL(常雪灵); Jing L(荆隆); Zhao YL(赵宇亮); Zhang, MY; Xing, GM; Yuan, H; Chang, XL; Jing, L; Zhao, YL; Zhu, CF; Fang, XH
2010
发表期刊JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷号10期号:12页码:8556-8561
通讯作者[Zhang, Mingyi ; Xing, Gengmei ; Yuan, Hui ; Chang, Xueling ; Jing, Long ; Zhao, Yuliang] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Zhang, Mingyi ; Xing, Gengmei ; Yuan, Hui ; Chang, Xueling ; Jing, Long ; Zhao, Yuliang] Natl Ctr Nanosci & Technol China, Beijing 100049, Peoples R China ; [Zhu, Chuanfeng ; Fang, Xiaohong] Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China
文章类型Article; Proceedings Paper
摘要We investigated whether multi-hydroxyl metallofullerenes can penetrate into erythrocyte and whether this potential transmembrane delivery requires aggregated nanostructure of these particles. The metal atom encapsulated in metallofullerenes was used as a quantitative marker to investigate body distribution of aggregated nanoparticles in cytomembrane and cytoplasm. Image of atomic force microscopy (AFM) and assay of inductively coupled plasma-mass spectrometry (ICP-MS) suggested that aggregated 22 [Gd@C-82(OH)(22)](n) particles traversed through cytomembrane into belonged cytoplasm. Aggregated Gd nanostructure to small sphere with average diameter of, 22.4 +/- 0.5 nm. For pristine Gd@C-82 molecule, due to the electron donation from Gd atom, the distribution of electrons on the surface of carbon cage was localized. The electrophilic additive reaction of polyhydroxyl on the surface of Gd@C-82 was directly affected by local distribution of electrons. This resulted in local distribution of hydroxyls on the surface of Gd nanoparticles. Local distribution of hydroxyls brought about polar and nonpolar domains on particle surface, which induced Gd@C-82(OH)(22) to be amphiphilic molecule with due hydrophilic and hydrophobic properties. Amphiphilic properties of these molecules promoted their mutual aggregation in water. In the process of aggregation, amphiphilic properties of aggregated nanoparticles were well maintained, and besides, hydrophilic and hydrophobic domains were also regularly distributed on the surface of 22, [Gd@C-82(OH)(22)](n) particles. The amphiphilic nanoparticles attached externally to cytomembrane of, erythrocyte might be effectively driven by hydrophobic effect when they directly contacted cytomembrane of erythrocyte. The number of 22, [Gd@C-82(OH)(22)](n) nanoparticles attached to cytomembrane,n reached up to a certain crilical threshold, a significant curvature tension of membrane would occur. The shape of cell was accordingly changed. Increased membrane tension triggered the sudden opening of specific pores as a result of cytmennbrane response to nanoparitcle effect and the 22 [Gd@C-82(OH)(22)](n) nanoparticles gained entry to cell via these pores. This process was biologically independent of caveolar-mediated endocytosis or transportation pathway via ion channels.
关键词Transmembrane Delivery Gd@C-82(OH)(22) Erythrocyte
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics ; Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
DOI10.1166/jnn.2010.2490
URL查看原文
语种英语
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics ; Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号WOS:000283621400093
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/240142
专题多学科研究中心
加速器中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Zhang MY,Xing GM,Yuan H,et al. Transmembrane Delivery of Aggregated [Gd@C-82(OH)(22)](n) Nanoparticles[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(12):8556-8561.
APA 张铭倚.,邢更妹.,袁慧.,常雪灵.,荆隆.,...&Fang, XH.(2010).Transmembrane Delivery of Aggregated [Gd@C-82(OH)(22)](n) Nanoparticles.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,10(12),8556-8561.
MLA 张铭倚,et al."Transmembrane Delivery of Aggregated [Gd@C-82(OH)(22)](n) Nanoparticles".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 10.12(2010):8556-8561.
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