In Vitro Cytotoxicity of Transparent Yellow Iron Oxide Nanoparticles on Human Glioma Cells
Wang Y(王云); Zhu MT(朱墨桃); Wang B(汪冰); Wang M(王萌); Wang HJ(王华建); Ou YH(欧阳宏); Feng WY(丰伟悦); Yun, W; Zhu, MT; Bing, W; Meng, W; Wang, HJ; Hong, OY; Feng, WY
刊名JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
2010
卷号10期号:12页码:8550-8555
关键词Iron Oxide Yellow Nanoparticles Cytotoxicity Human Glioma Cell
学科分类Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1166/jnn.2010.2487
通讯作者[Yun Wang ; Zhu, Mo-Tao ; Bing Wang ; Meng Wang ; Wang, Hua-jian ; Hong OuYang ; Feng, Wei-Yue] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Yun Wang ; Zhu, Mo-Tao ; Bing Wang ; Meng Wang ; Wang, Hua-jian ; Hong OuYang ; Feng, Wei-Yue] Chinese Acad Sci, Key Lab Nucl Analyt Tech, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Yun Wang ; Zhu, Mo-Tao ; Wang, Hua-jian] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
文章类型Article; Proceedings Paper
英文摘要With rapid development of nanotechnology, concerns about the possible adverse health effects on human beings by using nanomaterials have been raised. Transparent yellow iron oxide (alpha-FeOOH) nanoparticles have been widely used in paints, plastic, rubber, building materials, papermaking, food products and pharmaceutical industry, thus the potential health implications by the exposure should be considered. The purpose of this study is to assess the cytotoxicity of transparent yellow iron oxide nanoparticles on U251 human glioma cells. The alpha-FeOOH nanoparticles are in clubbed shapes with 9 nm in diameter and 43 nm long. The specific surface area is 115.3 m(2)/g. After physicochemical characterization of the nanoparticles, U251 cells were exposed to alpha-FeOOH at the doses of 0, 3.75, 15, 60 and 120 mu g/mL. The results showed that the alpha-FeOOH nanoparticles reduced the cell viability and induced necrosis and apoptosis in U251 cells. In addition, nanoparticle exposure significantly increased the levels of superoxide anion and nitric oxide in a dose-dependent fashion in the cells. Our results suggest that exposure to alpha-FeOOH nanoparticles induce significant free radical formation and cytotoxic effects. The large surface area that induced high surface reactivity may play an important role in the cytotoxic effect of alpha-FeOOH nanoparticles.
类目[WOS]Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
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语种英语
WOS记录号WOS:000283621400092
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/240141
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_加速器中心
中国科学院高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Wang Y,Zhu MT,Wang B,et al. In Vitro Cytotoxicity of Transparent Yellow Iron Oxide Nanoparticles on Human Glioma Cells[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(12):8550-8555.
APA 王云.,朱墨桃.,汪冰.,王萌.,王华建.,...&Feng, WY.(2010).In Vitro Cytotoxicity of Transparent Yellow Iron Oxide Nanoparticles on Human Glioma Cells.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,10(12),8550-8555.
MLA 王云,et al."In Vitro Cytotoxicity of Transparent Yellow Iron Oxide Nanoparticles on Human Glioma Cells".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 10.12(2010):8550-8555.
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