Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods
Qiu, Y; Liu, Y; Wang, LM; Xu, LG; Bai, R; Ji, YL; Wu, XC; Zhao, YL; Li, YF; Chen, CY; Zhao YL(赵宇亮); Li YF(李玉锋); Chen CY(陈春英)
刊名BIOMATERIALS
2010
卷号31期号:30页码:7606-7619
关键词Gold Nanoparticles Nanorods Cytotoxicity Aspect ratio Surface modification
学科分类Engineering; Materials Science
DOI10.1016/j.biomaterials.2010.06.051
通讯作者[Qiu, Yang ; Liu, Ying ; Wang, Liming ; Xu, Ligeng ; Bai, Ru ; Ji, Yinglu ; Zhao, Yuliang ; Chen, Chunying] Natl Ctr Nanosci & Technol China, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China ; [Zhao, Yuliang ; Li, Yufeng ; Chen, Chunying] Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Ji, Yinglu ; Wu, Xiaochun] Natl Ctr Nanosci & Technol China, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China
文章类型Article
英文摘要Gold nanorods (Au NRs) have been recognized as promising materials for biomedical applications, like sensing, imaging, gene and drug delivery and therapy, but their toxicological issues are still controversial, especially for the Au NRs synthesized with seed-mediated method. In this study, we investigated the influence of aspect ratio and surface coating on their toxicity and cellular uptake. The cellular uptake is highly dependent on the aspect ratio and surface coating. However, the surface chemistry has the dominant roles since PDDAC-coated Au NRs exhibit a much greater ability to be internalized by the cells. The present data demonstrated shape-independent but coating-dependent cytotoxicity. Both the CTAB molecules left in the suspended solution and on the surface of Au NRs were identified as the actual cause of cytotoxicity. CTAB can enter cells with or without Au NRs, damage mitochondria, and then induce apoptosis. The effects of surface coating upon toxicity and cellular uptake were also examined using Au NRs with different coatings. When Au NRs were added into the medium, the proteins were quickly adsorbed onto the Au NRs that made the surface negatively charged. The surface charge may not directly affect the cellular uptake. We further demonstrated that the amount of serum proteins, especially for BSA, adsorbed on the Au NRs had a positive correlation with the capacity of Au NRs to enter cells. In addition, we have successfully revealed that the cationic PDDAC-coated Au NRs with an aspect ratio of 4 possess an ideal combination of both negligible toxicity and high cellular uptake efficiency, showing a great promise as photothermal therapeutic agents. (C) 2010 Elsevier Ltd. All rights reserved.
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
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语种英语
WOS记录号WOS:000281498600002
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被引频次:296[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/240126
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_实验物理中心
中国科学院高能物理研究所_加速器中心
中国科学院高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
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Qiu, Y,Liu, Y,Wang, LM,et al. Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods[J]. BIOMATERIALS,2010,31(30):7606-7619.
APA Qiu, Y.,Liu, Y.,Wang, LM.,Xu, LG.,Bai, R.,...&陈春英.(2010).Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods.BIOMATERIALS,31(30),7606-7619.
MLA Qiu, Y,et al."Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods".BIOMATERIALS 31.30(2010):7606-7619.
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