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A Nanocomplex System as Targeted Contrast Agent Delivery Vehicle for Magnetic Resonance Imaging Dynamic Contrast Enhancement Study
Korotcov, A; Shan, LA; Meng, HA; Wang, TX; Sridhar, R; Zhao, YL; Liang, XJ; Wang, PC; Meng H(孟幻); Zhao YL(赵宇亮)
2010
发表期刊JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷号10期号:11页码:7545-7549
通讯作者[Korotcov, Alexandru ; Shan, Liang ; Wang, Tongxin ; Wang, Paul C.] Howard Univ, Dept Radiol, Washington, DC 20060 USA ; [Meng, Huan ; Zhao, Yuliang] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Liang, Xing-Jie] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China ; [Sridhar, Rajagopalan] Howard Univ, Dept Radiat Oncol, Washington, DC 20060 USA
文章类型Article; Proceedings Paper
摘要We have developed and tested a liposomal nanocomplex system, which contains Gd-DTPA as a payload and transferrin on the surface, as a tumor specific targeting MRI contrast agent for studying prostate cancer tumors in mice. In vivo, the probe significantly enhanced the MRI signal. The image contrast between the peripheral region of the tumor and the non-involved muscle was nearly 50% higher two hours after administration of the nanocomplex. The liposomal nanocomplex increased the amount of Gd accumulated in tumors by factor 2.8 compared to that accumulated by using Magnevist alone. Moreover, the heterogeneous MRI image features correlate well with the tumor pathology. The image enhancement patterns can be used for cancer prognosis and non-invasive monitoring of the response to therapy.
关键词Targeted Drug Delivery Dynamic Contrast Enhancement (DCE)-MRI Cancer Liposome Transferrin Nanoparticle
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1166/jnn.2010.2821
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语种英语
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号WOS:000283621300128
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被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/240122
专题多学科研究中心
作者单位中国科学院高能物理研究所
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Korotcov, A,Shan, LA,Meng, HA,et al. A Nanocomplex System as Targeted Contrast Agent Delivery Vehicle for Magnetic Resonance Imaging Dynamic Contrast Enhancement Study[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(11):7545-7549.
APA Korotcov, A.,Shan, LA.,Meng, HA.,Wang, TX.,Sridhar, R.,...&赵宇亮.(2010).A Nanocomplex System as Targeted Contrast Agent Delivery Vehicle for Magnetic Resonance Imaging Dynamic Contrast Enhancement Study.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,10(11),7545-7549.
MLA Korotcov, A,et al."A Nanocomplex System as Targeted Contrast Agent Delivery Vehicle for Magnetic Resonance Imaging Dynamic Contrast Enhancement Study".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 10.11(2010):7545-7549.
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