|A Nanocomplex System as Targeted Contrast Agent Delivery Vehicle for Magnetic Resonance Imaging Dynamic Contrast Enhancement Study|
|Korotcov, A; Shan, LA; Meng, HA; Wang, TX; Sridhar, R; Zhao, YL; Liang, XJ; Wang, PC; Meng H(孟幻); Zhao YL(赵宇亮)
|发表期刊||JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
; Shan, Liang
; Wang, Tongxin
; Wang, Paul C.] Howard Univ, Dept Radiol, Washington, DC 20060 USA
; [Meng, Huan
; Zhao, Yuliang] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
; [Liang, Xing-Jie] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
; [Sridhar, Rajagopalan] Howard Univ, Dept Radiat Oncol, Washington, DC 20060 USA
|摘要||We have developed and tested a liposomal nanocomplex system, which contains Gd-DTPA as a payload and transferrin on the surface, as a tumor specific targeting MRI contrast agent for studying prostate cancer tumors in mice. In vivo, the probe significantly enhanced the MRI signal. The image contrast between the peripheral region of the tumor and the non-involved muscle was nearly 50% higher two hours after administration of the nanocomplex. The liposomal nanocomplex increased the amount of Gd accumulated in tumors by factor 2.8 compared to that accumulated by using Magnevist alone. Moreover, the heterogeneous MRI image features correlate well with the tumor pathology. The image enhancement patterns can be used for cancer prognosis and non-invasive monitoring of the response to therapy.|
|文章类型||Article; Proceedings Paper
|关键词||Targeted Drug Delivery
Dynamic Contrast Enhancement (DCE)-MRI
|学科领域||Chemistry; Science & Technology - Other Topics; Materials Science; Physics
; Science & Technology - Other Topics
; Materials Science
; Nanoscience & Nanotechnology
; Materials Science, Multidisciplinary
; Physics, Applied
; Physics, Condensed Matter
Korotcov, A,Shan, LA,Meng, HA,et al. A Nanocomplex System as Targeted Contrast Agent Delivery Vehicle for Magnetic Resonance Imaging Dynamic Contrast Enhancement Study[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(11):7545-7549.
Korotcov, A.,Shan, LA.,Meng, HA.,Wang, TX.,Sridhar, R.,...&赵宇亮.(2010).A Nanocomplex System as Targeted Contrast Agent Delivery Vehicle for Magnetic Resonance Imaging Dynamic Contrast Enhancement Study.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,10(11),7545-7549.
Korotcov, A,et al."A Nanocomplex System as Targeted Contrast Agent Delivery Vehicle for Magnetic Resonance Imaging Dynamic Contrast Enhancement Study".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 10.11(2010):7545-7549.