Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis
Liang, XJ; Meng H(孟幻); Meng J(孟洁); Zhao YL(赵宇亮); Gao XY(高学云); Sun BY(孙宝云); Xing GM(邢更妹); Meng, H; Wang, YZ; He, HY; Meng, J; Lu, J; Wang, PC; Zhao, YL; Gao, XY; Sun, BY; Chen, CY; Xing, GM; Shen, DW; Gottesman, MM; Wu, Y; Yin, JJ; Jia, L
刊名PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2010
卷号107期号:16页码:7449-7454
关键词drug resistance nanomedicine nanoimaging chemotherapy nanopharmaceutical
学科分类Science & Technology - Other Topics
DOI10.1073/pnas.0909707107
通讯作者[Liang, Xing-Jie ; Wang, Yingze ; He, Haiyong ; Meng, Jie ; Lu, Juan ; Chen, Chunying ; Wu, Yan] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China ; [Meng, Huan ; Meng, Jie ; Zhao, Yuliang ; Gao, Xueyun ; Sun, Baoyun ; Xing, Genmei] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Wang, Paul C.] Howard Univ, Dept Radiol, Lab Mol Imaging, Washington, DC 20060 USA ; [Shen, Dingwu ; Gottesman, Michael M.] NCI, Cell Biol Lab, NIH, Bethesda, MD 20892 USA ; [Yin, Jun-jie] US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD 20740 USA ; [Jia, Lee] NCI, Dev Therapeut Program, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA
文章类型Article
英文摘要Cisplatin is a chemotherapeutic drug commonly used in clinics. However, acquired resistance confines its application in chemotherapeutics. To overcome the acquired resistance to cisplatin, it is reasoned, based on our previous findings of mediation of cellular responses by [Gd@C(82)(OH)(22)](n) nanoparticles, that [Gd@C(82)(OH)(22)](n) may reverse tumor resistance to cisplatin by reactivating the impaired endocytosis of cisplatin-resistant human prostate cancer (CP-r) cells. Here we report that exposure of the CP-r PC-3-luc cells to cisplatin in the presence of nontoxic [Gd@C(82)(OH)(22)](n) not only decreased the number of surviving CP-r cells but also inhibited growth of the CP-r tumors in athymic nude mice as measured by both optical and MRI. Labeling the CP-r PC-3 cells with transferrin, an endocytotic marker, demonstrated that pretreatment of the CP-r PC-3-luc cells with [Gd@C(82)(OH)(22)](n) enhanced intracellular accumulation of cisplatin and formation of cisplatin-DNA adducts by restoring the defective endocytosis of the CP-r cancer cells. The results suggest that [Gd@C(82)(OH)(22)](n) nanoparticles overcome tumor resistance to cisplatin by increasing its intracellular accumulation through the mechanism of restoring defective endocytosis. The technology can be extended to other challenges related to multidrug resistance often found in cancer treatments.
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
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语种英语
WOS记录号WOS:000276892300062
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文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/240118
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_实验物理中心
中国科学院高能物理研究所_加速器中心
中国科学院高能物理研究所_多学科研究中心
中国科学院高能物理研究所_中国散裂中子源
作者单位中国科学院高能物理研究所
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Liang, XJ,Meng H,Meng J,et al. Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2010,107(16):7449-7454.
APA Liang, XJ.,孟幻.,孟洁.,赵宇亮.,高学云.,...&Jia, L.(2010).Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,107(16),7449-7454.
MLA Liang, XJ,et al."Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107.16(2010):7449-7454.
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