Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents
Miao, QH; Xu, DX; Wang, Z; Xu, L; Wang, TW; Wu, Y; Lovejoy, DB; Kalinowski, DS; Richardson, DR; Nie, GJ; Zhao, YL; Zhao YL(赵宇亮)
刊名BIOMATERIALS
2010
卷号31期号:28页码:7364-7375
关键词Controlled drug release Cytotoxicity Drug delivery Nanoparticle
学科分类Engineering; Materials Science
DOI10.1016/j.biomaterials.2010.06.012
通讯作者[Lovejoy, David B. ; Kalinowski, Danuta S. ; Richardson, Des R.] Univ Sydney, Dept Pathol, Sydney, NSW 2006, Australia ; [Lovejoy, David B. ; Kalinowski, Danuta S. ; Richardson, Des R.] Univ Sydney, Bosch Inst, Sydney, NSW 2006, Australia ; [Miao, Qinghua ; Xu, Dongxue ; Wang, Tiewei ; Wu, Yan ; Nie, Guangjun ; Zhao, Yuliang] CAS, Key Lab Biol Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China ; [Miao, Qinghua ; Xu, Dongxue ; Wang, Zhi ; Xu, Li] Jilin Univ, Minist Educ, Key Lab Mol Enzymol & Engn, Changchun 130023, Peoples R China ; [Zhao, Yuliang] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing, Peoples R China
文章类型Article
英文摘要In this investigation, we have designed and synthesized an amphiphilic co-polymer with hyper-branched poly(amine-ester) and polylactide (HPAE-co-PLA) to generate nanoparticles (NPs). These have been used to encapsulate a highly active hydrophobic anti-tumor agent, 2-benzoylpyridine 4-ethyl-3-thiosemicarbazone (Bp4eT). Encapsulation in NPs was done in an effort to increase the anti-tumor activity of this agent by facilitating its delivery to tumor cells. We have also examined and optimized the formulation parameters of the NPs that alter their drug-loading capacity and their physical, chemical and biological properties. The resulting NPs exhibited high Bp4eT-loading capacity and substantial stability in aqueous solution. In vitro drug release studies demonstrated a controlled drug release profile with increased release at acidic pH. Anti-tumor proliferation assays showed that both free drug and drug-encapsulated NPs markedly inhibited tumor cell proliferation in a time- and concentration-dependent manner. Direct microscopic observation revealed that the fluorescent NPs were taken up by cells and localized, in part, in organelles consistent with lysosomes. These results demonstrate a feasible application of the amphiphilic hyper-branched co-polymer, HPAE-co-PLA, as nanocarriers for intracellular delivery of potent anti-tumor agents. (C) 2010 Elsevier Ltd. All rights reserved.
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
原文出处查看原文
语种英语
WOS记录号WOS:000281183000016
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文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/240113
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
作者单位中国科学院高能物理研究所
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Miao, QH,Xu, DX,Wang, Z,et al. Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents[J]. BIOMATERIALS,2010,31(28):7364-7375.
APA Miao, QH.,Xu, DX.,Wang, Z.,Xu, L.,Wang, TW.,...&赵宇亮.(2010).Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents.BIOMATERIALS,31(28),7364-7375.
MLA Miao, QH,et al."Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents".BIOMATERIALS 31.28(2010):7364-7375.
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