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Mononuclear copper(II) complexes with 3,5-substituted-4-salicylidene-amino-3,5-dimethyl-1,2,4-triazole: synthesis, structure and potent inhibition of protein tyrosine phosphatases
Ma, L; Lu, LP; Zhu, ML; Wang, QM; Li, Y; Xing, S; Fu, XQ; Gao, ZQ; Dong, YH; Gao ZQ(高增强); Dong YH(董宇辉)
2011
发表期刊DALTON TRANSACTIONS
卷号40期号:24页码:6532-6540
通讯作者[Ma, Ling ; Lu, Liping ; Zhu, Miaoli ; Wang, Qingming ; Li, Ying] Shanxi Univ, Educ Minist, Inst Mol Sci, Key Lab Chem Biol & Mol Engn, Taiyuan 030006, Shanxi, Peoples R China ; [Xing, Shu ; Fu, Xueqi] Jilin Univ, Coll Life Sci, Edmond H Fischer Signal Transduct Lab, Changchun 130023, Peoples R China ; [Zhu, Miaoli ; Gao, Zengqiang ; Dong, Yuhui] Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Facil, Beijing 100049, Peoples R China
摘要Six copper complexes of Schiff base ligands containing 3,5-substituted-4-salicylideneamino-3,5-dimethyl-1,2,4-triazole have been synthesized and well characterized. The structures of complexes 1 and 2 were determined by X-ray crystal analysis. Fluorescence and potentiometric study indicated that in the physiological pH range, one ligand was dissociated from the complexes to form 1 : 1 mononucleus copper complexes. The complexes potently inhibit protein tyrosine phosphatase 1B (PTP1B), T-cell protein tyrosine phosphatase (TCPTP), megakaryocyte protein tyrosine phosphatase 2 (PTP-MEG2) and Src homology phosphatase 1 (SHP-1) with 3-4 fold selectivity against PTP1B over TCPTP and PTP-MEG2, and 3-9 fold over SHP-1, but display almost no inhibition against Src homology phosphatase 2 (SHP-2). Complex 1 inhibits PTP1B with a competitive model with K-i of 30 nM. Substitution with small groups at the phenyl of the ligand does not obviously influence the inhibitory ability of the complexes.
文章类型Article
学科领域Chemistry
研究领域[WOS]Chemistry
DOI10.1039/c1dt10169b
URL查看原文
语种英语
WOS类目Chemistry, Inorganic & Nuclear
WOS记录号WOS:000291385700029
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被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/240081
专题多学科研究中心
核技术应用研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Ma, L,Lu, LP,Zhu, ML,et al. Mononuclear copper(II) complexes with 3,5-substituted-4-salicylidene-amino-3,5-dimethyl-1,2,4-triazole: synthesis, structure and potent inhibition of protein tyrosine phosphatases[J]. DALTON TRANSACTIONS,2011,40(24):6532-6540.
APA Ma, L.,Lu, LP.,Zhu, ML.,Wang, QM.,Li, Y.,...&董宇辉.(2011).Mononuclear copper(II) complexes with 3,5-substituted-4-salicylidene-amino-3,5-dimethyl-1,2,4-triazole: synthesis, structure and potent inhibition of protein tyrosine phosphatases.DALTON TRANSACTIONS,40(24),6532-6540.
MLA Ma, L,et al."Mononuclear copper(II) complexes with 3,5-substituted-4-salicylidene-amino-3,5-dimethyl-1,2,4-triazole: synthesis, structure and potent inhibition of protein tyrosine phosphatases".DALTON TRANSACTIONS 40.24(2011):6532-6540.
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