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Potential Health Impact on Mice after Nasal Instillation of Nano-Sized Copper Particles and Their Translocation in Mice
Liu Y(刘洋); Gao YX(高愈希); Zhang LL(张丽丽); Wang JX(王江雪); Jiao F(焦芳); Li W(李炜); Liu Y(刘颖); Li YF(李玉锋); Li B(李柏); Chai ZF(柴之芳); Chen CY(陈春英); Liu, Y; Gao, YX; Zhang, LL; Wang, TC; Wang, JX; Jiao, F; Li, W; Liu, Y; Li, YF; Li, B; Chai, ZF; Wu, G; Chen, CY
2009
发表期刊JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷号9期号:11页码:6335-6343
通讯作者[Liu, Yang ; Wu, Gang] Baotou Med Coll, Dept Basic Med, Baotou 014010, Peoples R China ; [Chai, Zhifang] Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China ; [Wang, Tiancheng] Peking Univ, Hosp 3, Dept Clin Lab Med, Beijing 100083, Peoples R China ; [Liu, Yang ; Gao, Yuxi ; Zhang, Lili ; Wang, Jiangxue ; Jiao, Fang ; Li, Wei ; Liu, Ying ; Li, Yufeng ; Li, Bai ; Chai, Zhifang ; Chen, Chunying] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China ; [Liu, Yang ; Gao, Yuxi ; Zhang, Lili ; Wang, Jiangxue ; Jiao, Fang ; Li, Wei ; Liu, Ying ; Li, Yufeng ; Li, Bai ; Chai, Zhifang ; Chen, Chunying] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [Liu, Yang ; Gao, Yuxi ; Zhang, Lili ; Wang, Jiangxue ; Jiao, Fang ; Li, Wei ; Liu, Ying ; Li, Yufeng ; Li, Bai ; Chai, Zhifang ; Chen, Chunying] Chinese Acad Sci, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
文章类型Article
摘要The purpose of this study is to evaluate the overall toxicity of nasal instilled nanoscale copper particles (23.5 nm) in mice. Pathological examination, target organs identification, and blood biochemical assay of experimental mice were carried out in comparison with micro-sized copper particles (17 mu m). However, only in the high-dose group of copper nanoparticles (40 mg/kg body weight instilled for three times in one week), the body weight of mice were retarded and significant pathological changes were observed. There were hydropic degeneration around the central vein and the spotty necrosis of hepatocytes in the liver and swelling in the renal glomerulus, while, severe lesion associated with the decreased number of olfactory cells and the dilapidated laminated structure were also observed in the olfactory bulb. The serum biochemical assay also indicated the sign of renal and hepatic lesion. However, there were no obvious pathological and physiological damages in the mice after instilling different-sized copper nanoparticles with low dose of 1 mg/kg body weight. The retention and distribution of copper in various tissues show that the liver, kidneys and olfactory bulb are the main accumulated tissues for copper particles, which were determined by high sensitive element-specific technique of ICP-MS. The copper contents of the liver, kidneys and the olfactory bulb increase significantly at the group of 40 mg/kg compared to the control group, which is in agreement with the histological changes. Therefore, the data indicate that nasal inhaled copper particles at very high dosage can translocate to other organs and tissues and further induce certain lesions. The present results are helpful to get better understanding of the risk assessment and evaluation for copper nanoparticles.
关键词Copper Nanoparticles Nasal Instillation Translocation Toxicity Mice
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1166/jnn.2009.1320
URL查看原文
语种英语
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号WOS:000270471100011
引用统计
被引频次:48[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/240070
专题院士
实验物理中心
加速器中心
多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Liu Y,Gao YX,Zhang LL,et al. Potential Health Impact on Mice after Nasal Instillation of Nano-Sized Copper Particles and Their Translocation in Mice[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2009,9(11):6335-6343.
APA 刘洋.,高愈希.,张丽丽.,王江雪.,焦芳.,...&Chen, CY.(2009).Potential Health Impact on Mice after Nasal Instillation of Nano-Sized Copper Particles and Their Translocation in Mice.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,9(11),6335-6343.
MLA 刘洋,et al."Potential Health Impact on Mice after Nasal Instillation of Nano-Sized Copper Particles and Their Translocation in Mice".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 9.11(2009):6335-6343.
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