Mouse blood vessel imaging by in-line x-ray phase-contrast imaging
Zhang, X; Liu, XS; Yang, XR; Chen, SL; Zhu, PP; Yuan, QX; Liu XS(刘小松); Zhu PP(朱佩平); Yuan QX(袁清习)
刊名PHYSICS IN MEDICINE AND BIOLOGY
2008
卷号53期号:20页码:5735-5743
学科分类Engineering; Radiology, Nuclear Medicine & Medical Imaging
DOI10.1088/0031-9155/53/20/011
通讯作者[Zhang, Xi ; Chen, Shao-Liang] Fudan Univ, Affiliated ZhongShan Hosp, Dept Nucl Med, Shanghai 200032, Peoples R China ; [Yang, Xin-Rong] Fudan Univ, ZhongShan Hosp, Liver Canc Inst, Shanghai 200032, Peoples R China ; [Liu, Xiao-Song ; Zhu, Pei-Ping ; Yuan, Qing-Xi] Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China
文章类型Article
英文摘要It is virtually impossible to observe blood vessels by conventional x-ray imaging techniques without using contrast agents. In addition, such x-ray systems are typically incapable of detecting vessels with diameters less than 200 mu m. Here we show that vessels as small as 30 mu m could be detected using in-line phase-contrast x-ray imaging without the use of contrast agents. Image quality was greatly improved by replacing resident blood with physiological saline. Furthermore, an entire branch of the portal vein from the main axial portal vein to the eighth generation of branching could be captured in a single phase-contrast image. Prior to our work, detection of 30 mu m diameter blood vessels could only be achieved using x-ray interferometry, which requires sophisticated x-ray optics. Our results thus demonstrate that in-line phase-contrast x-ray imaging, using physiological saline as a contrast agent, provides an alternative to the interferometric method that can be much more easily implemented and also offers the advantage of a larger field of view. A possible application of this methodology is in animal tumor models, where it can be used to observe tumor angiogenesis and the treatment effects of antineoplastic agents.
类目[WOS]Engineering, Biomedical ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Engineering ; Radiology, Nuclear Medicine & Medical Imaging
原文出处查看原文
语种英语
WOS记录号WOS:000259736400012
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/240045
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714
Zhang, X,Liu, XS,Yang, XR,et al. Mouse blood vessel imaging by in-line x-ray phase-contrast imaging[J]. PHYSICS IN MEDICINE AND BIOLOGY,2008,53(20):5735-5743.
APA Zhang, X.,Liu, XS.,Yang, XR.,Chen, SL.,Zhu, PP.,...&袁清习.(2008).Mouse blood vessel imaging by in-line x-ray phase-contrast imaging.PHYSICS IN MEDICINE AND BIOLOGY,53(20),5735-5743.
MLA Zhang, X,et al."Mouse blood vessel imaging by in-line x-ray phase-contrast imaging".PHYSICS IN MEDICINE AND BIOLOGY 53.20(2008):5735-5743.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
7547.pdf(970KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, X]的文章
[Liu, XS]的文章
[Yang, XR]的文章
百度学术
百度学术中相似的文章
[Zhang, X]的文章
[Liu, XS]的文章
[Yang, XR]的文章
必应学术
必应学术中相似的文章
[Zhang, X]的文章
[Liu, XS]的文章
[Yang, XR]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 7547.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。