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Comparison Study on the Antibacterial Activity of Nano- or Bulk-Cerium Oxide
Kuang, YS; He X(何潇); Zhang ZY(张智勇); Li YY(李媛媛); Zhang HF(张海凤); Ma YH(马宇辉); Chai ZF(柴之芳); He, X; Zhang, ZY; Li, YY; Zhang, HF; Ma, YH; Wu, ZQ; Chai, ZF
2011
Source PublicationJOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume11Issue:5Pages:4103-4108
Corresponding Author[He, Xiao ; Zhang, Zhiyong ; Li, Yuanyuan ; Zhang, Haifeng ; Ma, Yuhui ; Chai, Zhifang] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Nucl Analyt Tech, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Kuang, Yashu ; Wu, Zhenqiang] S China Univ Technol, Sch Biol Sci & Engn, Guangzhou 510641, Peoples R China ; [Li, Yuanyuan ; Zhang, Haifeng] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
SubtypeArticle
AbstractDue to the unique physical and chemical properties, nanosized cerium oxide (n-CeO(2)) has attracted considerable interest in many fields of research. The potential, the growing use and the mass production of n-CeO(2) have stimulated research on their potential impact on the environment and human health. However, the toxicological definition for CeO(2) nanoparticles (NPs) is still quite controversial. In the present work, we evaluated the antibacterial activity of CeO(2) NPs sized ca. 7 nm (7-CeO(2)), ca. 25 nm (25-CeO(2)) and their bulk counterpart (b-CeO(2)), using gram-negative Escherichia coli (E. coli). Our results suggest that all the three types of CeO(2) particles have antibacterial activity, and both the NPs are more toxic than b-CeO(2). The rise in intracellular ROS level induced by direct contact of particles with the surface of E. coli was involved in the mechanism for the antibacterial activity of CeO(2) NPs. Exposure to 25-CeO(2) could also impair the integrity of the outer membrane within E. coli cells. Due to agglomeration and negligible effect on membrane integrity, 7-CeO(2) did riot exhibit greater antibacterial activity than 25-CeO(2).
KeywordCerium Oxide Antibacterial Activity Particle Size
Subject AreaChemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1166/jnn.2011.3858
URL查看原文
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000290692400050
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Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/239959
Collection院士
多学科研究中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Kuang, YS,He X,Zhang ZY,et al. Comparison Study on the Antibacterial Activity of Nano- or Bulk-Cerium Oxide[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2011,11(5):4103-4108.
APA Kuang, YS.,何潇.,张智勇.,李媛媛.,张海凤.,...&Chai, ZF.(2011).Comparison Study on the Antibacterial Activity of Nano- or Bulk-Cerium Oxide.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,11(5),4103-4108.
MLA Kuang, YS,et al."Comparison Study on the Antibacterial Activity of Nano- or Bulk-Cerium Oxide".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 11.5(2011):4103-4108.
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