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The effect of Gd@C-82(OH)(22) nanoparticles on the release of Th1/Th2 cytokines and induction of TNF-alpha mediated cellular immunity
Liu, Y; Jiao F(焦芳); Li W(李炜); Zhou GQ(周国强); Sun BY(孙宝云); Xing GM(邢更妹); Dong JQ(董金泉); Zhao YL(赵宇亮); Chai ZF(柴之芳); Chen CY(陈春英); Jiao, F; Qiu, Y; Li, W; Lao, F; Zhou, GQ; Sun, BY; Xing, GM; Dong, JQ; Zhao, YL; Chai, ZF; Chen, CY
2009
发表期刊BIOMATERIALS
卷号30期号:23-24页码:3934-3945
通讯作者[Liu, Ying ; Qiu, Yang ; Lao, Fang ; Zhao, Yuliang ; Chen, Chunying] CAS, Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China ; [Jiao, Fang ; Li, Wei ; Zhou, Guoqiang ; Sun, Baoyun ; Xing, Genmei ; Dong, Jinquan ; Zhao, Yuliang ; Chai, Zhifang ; Chen, Chunying] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Jiao, Fang ; Li, Wei ; Zhou, Guoqiang ; Sun, Baoyun ; Xing, Genmei ; Dong, Jinquan ; Zhao, Yuliang ; Chai, Zhifang ; Chen, Chunying] Chinese Acad Sci, Key Lab Nucl Tech, Inst High Energy Phys, Beijing 100049, Peoples R China
摘要It is known that down-regulation of the immune response may be associated with the progenesis, development and prognosis of cancer or infectious diseases. Up-regulating the immune response in vivo is therefore a desirable strategy for clinical treatment. Here we report that poly-hydroxylated metallofullerenol (Gd@C-82(OH)(22)) has biomedical functions useful in anticancer therapy arising from immunomodulatory effects observed both in vivo and in vitro. We found that metallofullerenol can inhibit the growth of tumors, and shows specific immunomodulatory effects on T cells and macrophages. These effects include polarizing the cytokine balance towards Th1 (T-helper cell type 1) cytokines, decreasing the production of Th2 cytokines (IL-4, IL-5 and IL-6), and increasing the production of Th1 cytokines (IL-2, IFN-gamma and TNF-alpha) in the serum samples. Immune-system regulation by this nanomaterial showed dose-dependent behavior: at a low concentration, Gd@C-82(OH)(22) nanoparticles slightly affected the activity of immune cells in vitro, while at a high concentration, they markedly enhanced immune responses and stimulated immune cells to release more cytokines, helping eliminate abnormal cells. Gd@C-82(OH)(22) nanoparticles stimulated T cells and macrophages to release significantly greater quantities of TNF-alpha, which plays a key role in cellular immune processes. Gd@C-82(OH)(22) nanoparticles are more effective in inhibiting tumor growth in mice than some clinical anticancer drugs but have negligible side effects. The underlying mechanism for high anticancer activity may be attributed to the fact that this water-soluble nanomaterial effectively triggers the host immune system to scavenge tumor cells. (C) 2009 Elsevier Ltd. All rights reserved.
文章类型Article
关键词Nanoparticle Cytotoxicity Immune response Macrophage
学科领域Engineering; Materials Science
研究领域[WOS]Engineering ; Materials Science
DOI10.1016/j.biomaterials.2009.04.001
URL查看原文
语种英语
WOS类目Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号WOS:000267469300014
引用统计
被引频次:107[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/239953
专题院士
加速器中心
多学科研究中心
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714
Liu, Y,Jiao F,Li W,et al. The effect of Gd@C-82(OH)(22) nanoparticles on the release of Th1/Th2 cytokines and induction of TNF-alpha mediated cellular immunity[J]. BIOMATERIALS,2009,30(23-24):3934-3945.
APA Liu, Y.,焦芳.,李炜.,周国强.,孙宝云.,...&Chen, CY.(2009).The effect of Gd@C-82(OH)(22) nanoparticles on the release of Th1/Th2 cytokines and induction of TNF-alpha mediated cellular immunity.BIOMATERIALS,30(23-24),3934-3945.
MLA Liu, Y,et al."The effect of Gd@C-82(OH)(22) nanoparticles on the release of Th1/Th2 cytokines and induction of TNF-alpha mediated cellular immunity".BIOMATERIALS 30.23-24(2009):3934-3945.
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