Biosafety assessment of Gd@C-82(OH)(22) nanoparticles on Caenorhabditis elegans
Zhang, WD; Sun BY(孙宝云); Zhao YL(赵宇亮); Sun, BY; Zhang, LZ; Zhao, BL; Nie, GJ; Zhao, YL
刊名NANOSCALE
2011
卷号3期号:6页码:2636-2641
学科分类Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1039/c1nr10239g
通讯作者[Zhang, Wendi ; Nie, Guangjun ; Zhao, Yuliang] Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China ; [Sun, Baoyun ; Zhao, Yuliang] Chinese Acad Sci, Inst High Energy Phys, Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Zhang, Longze ; Zhao, Baolu] Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
文章类型Article
英文摘要Gd@C-82(OH)(22), a water-soluble endohedral metallofullerene derivative, has been proven to possess significant antineoplastic activity in mice. Toxicity studies of the nanoparticle have shown some evidence of low or non toxicity in mice and cell models. Here we employed Caenorhabditis elegans (C. elegans) as a model organism to further evaluate the short-and long-term toxicity of Gd@C-82(OH)(22) and possible behavior changes under normal and stress culture conditions. With treatment of Gd@C-82(OH)(22) at 0.01, 0.1, 1.0 and 10 mg ml(-1) within one generation (short-term), C. elegans showed no significant decrease in longevity or thermotolerance compared to the controls. Furthermore, when Gd@C-82(OH)(22) treatment was extended up to six generations (long-term), nontoxic effects to the nematodes were found. In addition, data from body length measurement, feeding rate and egg-laying assays with short-term treatment demonstrated that the nanoparticles have no significant impact on the individual growth, feeding behavior and reproductive ability, respectively. In summary, this work has shown that Gd@C-82(OH)(22) is tolerated well by worms and it has no apparent toxic effects on longevity, stress resistance, growth and behaviors that were observed in both adult and young worms. Our work lays the foundations for further developments of this anti-neoplastic agent for clinical applications.
类目[WOS]Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
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语种英语
WOS记录号WOS:000291663500038
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被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/239798
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
作者单位中国科学院高能物理研究所
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Zhang, WD,Sun BY,Zhao YL,et al. Biosafety assessment of Gd@C-82(OH)(22) nanoparticles on Caenorhabditis elegans[J]. NANOSCALE,2011,3(6):2636-2641.
APA Zhang, WD.,孙宝云.,赵宇亮.,Sun, BY.,Zhang, LZ.,...&Zhao, YL.(2011).Biosafety assessment of Gd@C-82(OH)(22) nanoparticles on Caenorhabditis elegans.NANOSCALE,3(6),2636-2641.
MLA Zhang, WD,et al."Biosafety assessment of Gd@C-82(OH)(22) nanoparticles on Caenorhabditis elegans".NANOSCALE 3.6(2011):2636-2641.
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