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An Anti-Tumor Nanoparticle, [Gd@C-82(OH)(22)]n, Induces Macrophage Activation
Wang, BB; Yang, D; Sun BY(孙宝云); Sun, BY; Wei, XY; Guo, H; Liu, XL; Ying, GG; Niu, RF; Zhang, N; Ma, YJ
2011
发表期刊JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷号11期号:3页码:2321-2329
通讯作者[Wang, Bingbing ; Wei, Xiyin ; Guo, Hua ; Liu, Xiaoli ; Ying, Guoguang ; Zhang, Ning ; Ma, Yongjie] Tianjin Med Univ, Canc Inst & Hosp, Cent Lab Oncol Dept,Res Ctr Basic Med Sci, Minst Educ,Key Lab Breast Canc Prevent & Therapy, Tianjin 300060, Peoples R China ; [Yang, De] Ctr Canc Res & Basic Res Program, Mol Immunoregulat Lab, Frederick, MD 21702 USA ; [Sun, Baoyun] Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Niu, Ruifang] Tianjin Med Univ, Canc Inst & Hosp, Publ Lab, Tianjin 300060, Peoples R China
文章类型Article
摘要[Gd@C-82(OH)(22)](n), a fullerene-based nanoparticle, exhibits potent anti-tumor effects in mouse tumor-bearing models without detectable toxicity and the pathological studies revealed a massive infiltration of leukocytes in the residual tumors of [Gd@C-82(OH)(22)](n)-treated mice. We report here that [Gd@C-82(OH)(22)](n) promotes macrophages secreting pro-inflammatory cytokines IL-6 and TNF-alpha, enhances the expression of MHC-II and costimulatory molecules such as CD40 and CD54, increases endocytosis and cell adhesion. Furthermore, [Gd@C-82(OH)(22)](n)-treated macrophages,n became functionally activated as illustrated by their capacity to activate allogeneic T cells. Taken together, our results indicate that [Gd@C-82(OH)(22)](n) nanoparticle is a potent activator of, macrophages, which may in part account for its potent anti-tumor effect.
关键词Nanoparticle [Gd@C-82(OH)(22)](n) Macrophage Immune Response Activation
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics ; Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
DOI10.1166/jnn.2011.3610
URL查看原文
语种英语
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics ; Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号WOS:000288102300072
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/239716
专题多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Wang, BB,Yang, D,Sun BY,et al. An Anti-Tumor Nanoparticle, [Gd@C-82(OH)(22)]n, Induces Macrophage Activation[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2011,11(3):2321-2329.
APA Wang, BB.,Yang, D.,孙宝云.,Sun, BY.,Wei, XY.,...&Ma, YJ.(2011).An Anti-Tumor Nanoparticle, [Gd@C-82(OH)(22)]n, Induces Macrophage Activation.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,11(3),2321-2329.
MLA Wang, BB,et al."An Anti-Tumor Nanoparticle, [Gd@C-82(OH)(22)]n, Induces Macrophage Activation".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 11.3(2011):2321-2329.
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