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Distribution of metalloproteins in hepatocellular carcinoma and surrounding tissues
Liu, YB; Li LN(李丽娜); Gao YX(高愈希); Chen CY(陈春英); Li B(李柏); He W(何伟); Huang YY(黄宇营); Chai ZF(柴之芳); Li, LN; Gao, YX; Chen, CY; Li, B; He, W; Huang, YY; Chai, ZF
2007
发表期刊HEPATO-GASTROENTEROLOGY
卷号54期号:80页码:2291-2296
通讯作者[Li, Lina ; Gao, Yuxi ; Chen, Chunying ; Li, Bai ; He, Wei ; Huang, Yuying ; Chai, Zhifang] Chinese Acad Sci, Multidisciplinary Res Ctr, Inst High Energy Phys, Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [Li, Lina ; Gao, Yuxi ; Chen, Chunying ; Li, Bai ; He, Wei ; Huang, Yuying ; Chai, Zhifang] Chinese Acad Sci, Multidisciplinary Res Ctr, Inst High Energy Phys, Lab Biol Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Liu, Yingbin] Zhejiang Univ, Affiliated Hosp 2, Dept Surg, Hangzhou 310027, Peoples R China ; [Li, Lina] Baotou Med Coll, Dept Basic Med, Baotou, Peoples R China
文章类型Article
摘要Background/Aims: The aim of this study was to investigate the relationship between metalloproteins distributions and cancer development in human liver tissues. Methodology: Proteins in the cytosol and microsome of tumor and surrounding nontumor tissues from five individuals with HCC were separated with isoelectric focusing. Zinc, iron, copper, and manganese contents in protein bands were measured with synchrotron radiation X-ray fluorescence. Results: In the cytosol, the metal contents in protein bands from tumor tissues were generally less than those from corresponding nontumor tissues, especially in the Fe-containing bands with isoelectric points of 6.5 and 8.0, and Cu, Zn-containing band of 5.5. However, reversed metal contents in Fe, Cu-containing band of 4.0 and Zn-containing bands of 3.9 and 4.3 were observed. In microsomes, the metal contents of protein bands were generally similar between tumor and nontumor tissues, but the Fe content in tumor tissues was 2.5-fold lower in the band of 5.9, the Cu and Zn contents were 2 and 3.5-fold higher in the band of 9.3, respectively, compared to that of nontumor tissues. Conclusions: Metal distributions among the detected metal-containing bands are distinguishable between tumor and nontumor tissues. The difference of the distribution may be involved in the carcinogenesis of the liver tissues.
关键词hepatocellular carcinoma metalloproteins microsome cytosol synchrotron radiation X-ray fluorescence isoelectric focusing
学科领域Gastroenterology & Hepatology; Surgery
研究领域[WOS]Gastroenterology & Hepatology ; Surgery ; Gastroenterology & Hepatology ; Surgery
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语种英语
研究领域[WOS]Gastroenterology & Hepatology ; Surgery ; Gastroenterology & Hepatology ; Surgery
WOS类目Gastroenterology & Hepatology ; Surgery
WOS记录号WOS:000251892800024
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文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/239711
专题院士
实验物理中心
多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Liu, YB,Li LN,Gao YX,et al. Distribution of metalloproteins in hepatocellular carcinoma and surrounding tissues[J]. HEPATO-GASTROENTEROLOGY,2007,54(80):2291-2296.
APA Liu, YB.,李丽娜.,高愈希.,陈春英.,李柏.,...&Chai, ZF.(2007).Distribution of metalloproteins in hepatocellular carcinoma and surrounding tissues.HEPATO-GASTROENTEROLOGY,54(80),2291-2296.
MLA Liu, YB,et al."Distribution of metalloproteins in hepatocellular carcinoma and surrounding tissues".HEPATO-GASTROENTEROLOGY 54.80(2007):2291-2296.
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