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Studies on anti-tumor and antimetastatic activities of fullerenol in a mouse breast cancer model
Jiao, F; Liu, Y; Qu, Y; Li, W; Zhou, GQ; Ge, CC; Li, YF; Sun, BY; Chen, CY; Li W(李炜); Zhou GQ(周国强); Ge CC(葛翠翠); Li YF(李玉锋); Sun BY(孙宝云); Chen CY(陈春英)
2010
发表期刊CARBON
卷号48期号:8页码:2231-2243
通讯作者[Jiao, Fang ; Liu, Ying ; Qu, Ying ; Li, Wei ; Zhou, Guoqiang ; Ge, Cuicui ; Li, Yufeng ; Sun, Baoyun ; Chen, Chunying] Chinese Acad Sci, Natl Ctr Nanosci & Technol China, Beijing 100049, Peoples R China ; [Jiao, Fang ; Liu, Ying ; Qu, Ying ; Li, Wei ; Zhou, Guoqiang ; Ge, Cuicui ; Li, Yufeng ; Sun, Baoyun ; Chen, Chunying] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Jiao, Fang ; Li, Wei ; Zhou, Guoqiang ; Ge, Cuicui ; Li, Yufeng ; Chen, Chunying] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China
摘要The purpose was to examine the anti-tumor and antimetastatic activities of fullerenol and their related mechanisms. Thirty EMT-6 tumor-bearing mice were injected intraperitoneally with 0.1 ml saline or 0.1 ml saline containing fullerenol C(60)(OH)(20) (0.08 and 0.4 mg/ml) daily for 16 days. Using tumor tissues, we investigated imbalances in the oxidative defense system and the expression of several angiogenesis factors. C(60)(OH)(20) exhibits anti-tumor and antimetastatic activities in EMT-6 breast cancer metastasis model. Treatment with C(60)(OH)(20) was found to modulate oxidative stress significantly. The expression of several angiogenesis factors was reduced in tumor tissues after treatment with fullerenol. Importantly, CD31 (also known as PECAM-1, platelet endothelial cell adhesion molecule) expression and vessel density were markedly reduced in tumors from fullerenol-treated mice compared with controls. Modulation of oxidative stress in tumor tissues, inhibition of the formation of angiogenesis factors, and subsequent reduction in tumor vessel density and the nutrient supply to tumor cells could be important mechanisms by which fullerenol aggregates inhibit tumor growth and suppress carcinoma metastasis in vivo. (C) 2010 Elsevier Ltd. All rights reserved.
文章类型Article
学科领域Chemistry; Materials Science
研究领域[WOS]Chemistry ; Materials Science
DOI10.1016/j.carbon.2010.02.032
URL查看原文
语种英语
WOS类目Chemistry, Physical ; Materials Science, Multidisciplinary
WOS记录号WOS:000277780500012
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被引频次:48[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/239696
专题多学科研究中心
实验物理中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Jiao, F,Liu, Y,Qu, Y,et al. Studies on anti-tumor and antimetastatic activities of fullerenol in a mouse breast cancer model[J]. CARBON,2010,48(8):2231-2243.
APA Jiao, F.,Liu, Y.,Qu, Y.,Li, W.,Zhou, GQ.,...&陈春英.(2010).Studies on anti-tumor and antimetastatic activities of fullerenol in a mouse breast cancer model.CARBON,48(8),2231-2243.
MLA Jiao, F,et al."Studies on anti-tumor and antimetastatic activities of fullerenol in a mouse breast cancer model".CARBON 48.8(2010):2231-2243.
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