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Multi hydroxylated [Gd@C-82(OH)(22)](n) nanoparticles: Antineoplastic activity of high efficiency and low toxicity
Chen CY(陈春英); Xing GM(邢更妹); Wang JX(王江雪); Zhao YL(赵宇亮); Li B(李柏); Sun J(孙进); Yuan H(袁慧); Gao YX(高义贤); Meng H(孟浩); Chen Z(陈真); Zhao F(赵峰); Chai ZF(柴之芳); Chen, CY; Xing, GM; Wang, JX; Zhao, YL; Li, B; Tang, J; Jia, G; Wang, TC; Sun, J; Xing, L; Yuan, H; Gao, YX; Meng, H; Chen, Z; Zhao, F; Chai, ZF; Fang, XH
2005
发表期刊NANO LETTERS
卷号5期号:10页码:2050-2057
通讯作者Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100049, Peoples R China ; Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Techniques, Beijing 100049, Peoples R China ; Peking Univ, Hosp 3, Dept Clin Lab, Sch Publ Hlth, Beijing 100083, Peoples R China ; Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China ; Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
摘要[Gd@C-82(OH)(22)](n) particles (22 nm in a saline solution) of a dose level as low as 10(-7) mol/kg exhibit a very high antineoplastic efficiency (similar to 60%) in mice. A dose increment of 1 x 10(-7) mol/kg increases the tumor inhibition rate 26%. [Gd@C-82(OH)(22)](n) particles have a strong capacity to improve immunity and interfere with tumor invasion in normal muscle cells, nearly without toxicity in vivo and in vitro. Unlike conventional antineoplastic chemicals, the high antitumor efficiency of nanoparticles is not due to toxic effects to cells because they do not kill the tumor cells directly and only about 0.05% of the used dose is found in the tumor tissues. Results suggest that fullerene derivatives with proper surface modifications and sizes may help realize the dream of tumor chemotherapeutics of high-efficacy and low-toxicity.
文章类型Article
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
DOI10.1021/nl051624b
URL查看原文
语种英语
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号WOS:000232623700038
引用统计
被引频次:206[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/239633
专题院士
实验物理中心
加速器中心
多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Chen CY,Xing GM,Wang JX,et al. Multi hydroxylated [Gd@C-82(OH)(22)](n) nanoparticles: Antineoplastic activity of high efficiency and low toxicity[J]. NANO LETTERS,2005,5(10):2050-2057.
APA 陈春英.,邢更妹.,王江雪.,赵宇亮.,李柏.,...&Fang, XH.(2005).Multi hydroxylated [Gd@C-82(OH)(22)](n) nanoparticles: Antineoplastic activity of high efficiency and low toxicity.NANO LETTERS,5(10),2050-2057.
MLA 陈春英,et al."Multi hydroxylated [Gd@C-82(OH)(22)](n) nanoparticles: Antineoplastic activity of high efficiency and low toxicity".NANO LETTERS 5.10(2005):2050-2057.
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