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The microtubule aster formation and its role in nuclear envelope assembly around the sperm chromatin in Xenopus egg extracts
Yang N(杨宁); Chen ZC(陈忠才); Tang XW(唐孝威); Yang, N; Chen, ZC; Lu, P; Zhang, CM; Zhai, ZH; Tang, XW
刊名CHINESE SCIENCE BULLETIN
2003
卷号48期号:18页码:1912-1918
关键词nuclear reassembly microtubule colchicine taxol Xenopus egg extracts
学科分类Science & Technology - Other Topics
DOI10.1360/03wc0198
通讯作者Peking Univ, Dept Cell Biol & Genet, Beijing 100871, Peoples R China ; Chinese Acad Sci, Inst High Energy Phys, Beijing 100039, Peoples R China ; Peking Univ, Coll Life Sci, Natl Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China
文章类型Article
英文摘要Nuclear envelope is a dynamic structure in the cell cycle. At the beginning of mitosis, nuclear envelope breaks down and its components disperse into the cytoplasm. At the end of mitosis, nuclear envelope reassembles using the dispersed components. Searching for the mechanisms of the nuclear disassembly and reassembly has for a long time been one of the key projects for cell biologists. In this report we show that microtubules take a role in the nuclear envelope assembly around the sperm chromatin in Xenopus egg extracts. Microtubule cytoskeleton has been demonstrated to take roles in the transport of intracellular membranes such as Golgi and ER vesicles. We found that the nuclear envelope assembly needs functional microtubules. At the beginning of the nuclear assembly, microtubules nucleated to form a microtubule aster around the centrosome at the base of the sperm head. Using the microtubule drug colchicine to disrupt the microtubule nucleation, nuclear envelope reassembly was seriously inhibited. If the microtubules were stabilized by taxol, another microtubule drug, the nuclear envelope reassembly was also interfered, although a significantly large aster formed around the chromatin. Based on these observations, we propose that microtubules play an important role in the nuclear envelope reassembly maybe by transporting the nuclear envelope precursors to the chromatin surfaces.
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
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语种英语
WOS记录号WOS:000185748100003
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文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/239577
专题院士_期刊论文
作者单位中国科学院高能物理研究所
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Yang N,Chen ZC,Tang XW,et al. The microtubule aster formation and its role in nuclear envelope assembly around the sperm chromatin in Xenopus egg extracts[J]. CHINESE SCIENCE BULLETIN,2003,48(18):1912-1918.
APA 杨宁.,陈忠才.,唐孝威.,Yang, N.,Chen, ZC.,...&Tang, XW.(2003).The microtubule aster formation and its role in nuclear envelope assembly around the sperm chromatin in Xenopus egg extracts.CHINESE SCIENCE BULLETIN,48(18),1912-1918.
MLA 杨宁,et al."The microtubule aster formation and its role in nuclear envelope assembly around the sperm chromatin in Xenopus egg extracts".CHINESE SCIENCE BULLETIN 48.18(2003):1912-1918.
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