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Toxicity of zinc oxide nanoparticles to zebrafish embryo: a physicochemical study of toxicity mechanism
Bai W(白伟); Zhang ZY(张智勇); He X(何潇); Ma YH(马宇辉); Zhao YL(赵宇亮); Chai ZF(柴之芳); Bai, W; Zhang, ZY; Tian, WJ; He, X; Ma, YH; Zhao, YL; Chai, ZF
2010
Source PublicationJOURNAL OF NANOPARTICLE RESEARCH
Volume12Issue:5Pages:1645-1654
Corresponding Author[Bai, Wei ; Zhang, Zhiyong ; He, Xiao ; Ma, Yuhui ; Zhao, Yuliang ; Chai, Zhifang] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Nucl Analyt Tech, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Tian, Wenjing] Qingdao Univ Sci & Technol, Coll Environm & Safety Engn, Qingdao 266061, Peoples R China
SubtypeArticle
AbstractThe biological impact of engineered nanomaterials released into the aquatic environment is a major concern. In this work, the properties of ZnO nanoparticles (nano-ZnO, 30 nm) were characterized in a water suspension (E3 medium), and a zebrafish 96-h post fertilization (hpf) embryo-larval test was performed to assess the toxicity of nano-ZnO suspension. Nano-ZnO was found to readily form aggregates with different sizes; small aggregates (142.4-517.7 nm) were still suspended in E3 medium, but large aggregates (> 1 mu m) quickly deposited on the bottom of 24-well plates; nano-ZnO was partially dissolved to Zn species (Zn((dis))) in E3 medium. In the nano-ZnO suspension, small aggregates, Zn((dis)), and large aggregates might jointly exert influence on the development of zebrafish embryos. The embryo toxicity test revealed that nano-ZnO killed zebrafish embryos (50 and 100 mg/L), retarded the embryo hatching (1-25 mg/L), reduced the body length of larvae, and caused tail malformation after the 96 hpf exposure. Zn((dis)) only partially contributed to the toxicity of nano-ZnO. This research highlights the need to further investigate the ecotoxicity of nano-ZnO in the water environment.
KeywordZnO nanoparticles Solubility Aggregate Toxicity Zebrafish embryo Environment EHS
Subject AreaChemistry; Science & Technology - Other Topics; Materials Science
DOI10.1007/s11051-009-9740-9
URL查看原文
Indexed BySCI ; ADS
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000277956800012
ADS Bibcode2010JNR....12.1645B
ADS URLhttps://ui.adsabs.harvard.edu/abs/2010JNR....12.1645B
ADS CITATIONShttps://ui.adsabs.harvard.edu/abs/2010JNR....12.1645B/citations
Citation statistics
Cited Times:41 [ADS]
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/239453
Collection院士
加速器中心
多学科研究中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Bai W,Zhang ZY,He X,et al. Toxicity of zinc oxide nanoparticles to zebrafish embryo: a physicochemical study of toxicity mechanism[J]. JOURNAL OF NANOPARTICLE RESEARCH,2010,12(5):1645-1654.
APA 白伟.,张智勇.,何潇.,马宇辉.,赵宇亮.,...&Chai, ZF.(2010).Toxicity of zinc oxide nanoparticles to zebrafish embryo: a physicochemical study of toxicity mechanism.JOURNAL OF NANOPARTICLE RESEARCH,12(5),1645-1654.
MLA 白伟,et al."Toxicity of zinc oxide nanoparticles to zebrafish embryo: a physicochemical study of toxicity mechanism".JOURNAL OF NANOPARTICLE RESEARCH 12.5(2010):1645-1654.
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