IHEP OpenIR  > 多学科研究中心
Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multi-wall nanotube, and fullerene
Jia, G; Wang, HF; Yan, L; Wang, X; Pei, RJ; Yan, T; Zhao, YL; Guo, XB; Zhao YL(赵宇亮)
2005
发表期刊ENVIRONMENTAL SCIENCE & TECHNOLOGY
卷号39期号:5页码:1378-1383
通讯作者Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100049, Peoples R China ; Peking Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Beijing 100083, Peoples R China ; Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
摘要A cytotoxicity test protocol for single-wall nanotubes (SWNTs), multi-wall nanotubes (with diameters ranging from 10 to 20 nm, MWNT10), and fullerene (C-60) was tested. Profound cytotoxicity of SWNTs was observed in alveolar macrophage (AM) after a 6-h exposure in vitro. The cytotoxicity increases by as high as similar to35% when the dosage of SWNTs was increased by 11.30 mug/cm(2). No significant toxicity was observed for C60 up to a dose of 226.00 mug/CM2. The cytotoxicity apparently follows a sequence order on a mass basis: SWNTs > MWNT10 > quartz > C-60. SWNTs significantly impaired phagocytosis of AM at the low dose of 0.38 mug/cm(2), whereas MWNT10 and C60 induced injury only at the high dose of 3.06 mug/cm(2). The macrophages exposed to SWNTs or MWNT10 of 3.06 mug/cm(2) showed characteristic features of necrosis and degeneration. A sign of apoptotic cell death likely existed. Carbon nanomaterials with different geometric structures exhibit quite different cytotoxicity and bioactivity in vitro, although they may not be accurately reflected in the comparative toxicity in vivo.
文章类型Article
学科领域Engineering; Environmental Sciences & Ecology
DOI10.1021/es048729l
研究领域[WOS]Engineering ; Environmental Sciences & Ecology
URL查看原文
语种英语
WOS类目Engineering, Environmental ; Environmental Sciences
WOS记录号WOS:000227257400034
引用统计
被引频次:847[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/239324
专题多学科研究中心
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714
Jia, G,Wang, HF,Yan, L,et al. Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multi-wall nanotube, and fullerene[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2005,39(5):1378-1383.
APA Jia, G.,Wang, HF.,Yan, L.,Wang, X.,Pei, RJ.,...&赵宇亮.(2005).Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multi-wall nanotube, and fullerene.ENVIRONMENTAL SCIENCE & TECHNOLOGY,39(5),1378-1383.
MLA Jia, G,et al."Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multi-wall nanotube, and fullerene".ENVIRONMENTAL SCIENCE & TECHNOLOGY 39.5(2005):1378-1383.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
6503.pdf(733KB)期刊论文作者接受稿限制开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Jia, G]的文章
[Wang, HF]的文章
[Yan, L]的文章
百度学术
百度学术中相似的文章
[Jia, G]的文章
[Wang, HF]的文章
[Yan, L]的文章
必应学术
必应学术中相似的文章
[Jia, G]的文章
[Wang, HF]的文章
[Yan, L]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。