Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multi-wall nanotube, and fullerene
Jia, G; Wang, HF; Yan, L; Wang, X; Pei, RJ; Yan, T; Zhao, YL; Guo, XB; Zhao YL(赵宇亮)
刊名ENVIRONMENTAL SCIENCE & TECHNOLOGY
2005
卷号39期号:5页码:1378-1383
学科分类Engineering; Environmental Sciences & Ecology
DOI10.1021/es048729l
通讯作者Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100049, Peoples R China ; Peking Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Beijing 100083, Peoples R China ; Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
文章类型Article
英文摘要A cytotoxicity test protocol for single-wall nanotubes (SWNTs), multi-wall nanotubes (with diameters ranging from 10 to 20 nm, MWNT10), and fullerene (C-60) was tested. Profound cytotoxicity of SWNTs was observed in alveolar macrophage (AM) after a 6-h exposure in vitro. The cytotoxicity increases by as high as similar to35% when the dosage of SWNTs was increased by 11.30 mug/cm(2). No significant toxicity was observed for C60 up to a dose of 226.00 mug/CM2. The cytotoxicity apparently follows a sequence order on a mass basis: SWNTs > MWNT10 > quartz > C-60. SWNTs significantly impaired phagocytosis of AM at the low dose of 0.38 mug/cm(2), whereas MWNT10 and C60 induced injury only at the high dose of 3.06 mug/cm(2). The macrophages exposed to SWNTs or MWNT10 of 3.06 mug/cm(2) showed characteristic features of necrosis and degeneration. A sign of apoptotic cell death likely existed. Carbon nanomaterials with different geometric structures exhibit quite different cytotoxicity and bioactivity in vitro, although they may not be accurately reflected in the comparative toxicity in vivo.
类目[WOS]Engineering, Environmental ; Environmental Sciences
研究领域[WOS]Engineering ; Environmental Sciences & Ecology
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语种英语
WOS记录号WOS:000227257400034
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被引频次:832[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/239324
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
作者单位中国科学院高能物理研究所
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GB/T 7714
Jia, G,Wang, HF,Yan, L,et al. Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multi-wall nanotube, and fullerene[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2005,39(5):1378-1383.
APA Jia, G.,Wang, HF.,Yan, L.,Wang, X.,Pei, RJ.,...&赵宇亮.(2005).Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multi-wall nanotube, and fullerene.ENVIRONMENTAL SCIENCE & TECHNOLOGY,39(5),1378-1383.
MLA Jia, G,et al."Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multi-wall nanotube, and fullerene".ENVIRONMENTAL SCIENCE & TECHNOLOGY 39.5(2005):1378-1383.
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