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Transport and absorption of chiral metal complexes d-[Co(EDTA)] and l-[Co(EDTA)](-) across Caco-2 cell monolayers
Mu, YP; Wu, G; Qiao, XW; Gao, YX; Zhou, LS; He, YL; Gao YX(高愈希)
2008
发表期刊CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
卷号29期号:7页码:1321-1324
通讯作者[Mu Yong-Ping ; Wu Gang ; Zhou Li-She] Baotou Med Coll, Dept Biochem & Mol Biol, Baotou 014010, Peoples R China ; [Qiao Xiu-Wen] Shihezi Univ, Sch Chem & Chem Engn, Shihezi 832002, Peoples R China ; [Gao Yu-Xi] Chinese Acad Sci, Key Lab Nucl Analyt Tech, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Wu Gang ; He Yan-Ling] Baotou Med Coll, Res Inst Trace Element Organism, Baotou 014010, Peoples R China
文章类型Article
摘要The trasport rate of chiral complexes d-[Co(EDTA)](-) and 1-[Co(EDTA)](-) across Caco-2 cell monolayers were measured by the kinetics method. The studies discover that there is an obvious difference about the trasport rate of d-[Co(EDTA)](-) and 1-[Co(EDTA)](-) when they get across Caco-2 cell monolayers because of the chiral difference of the metal complexes. The results show that there is a chiral selectivity when chiral metal complexes were transported and absorbed across Caco-2 cell monolayers and imply that intestine would selectively absorb drugs of chiral metal complexes. The trasport rate of d-[Co(EDTA)](-) and l-[Co(EDTA)](-) passing through Caco-2 cell monolayers depends on the grads of the complexes concentration, it is shown that their transport model is as simple diffuse when they were transported and absorbed through Caco-2 cell monolayers.
关键词chirality metal complex Caco-2 cell monolayer transpot absorption
学科领域Chemistry
研究领域[WOS]Chemistry ; Chemistry
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语种英语
研究领域[WOS]Chemistry ; Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000258092900007
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文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/239277
专题多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Mu, YP,Wu, G,Qiao, XW,et al. Transport and absorption of chiral metal complexes d-[Co(EDTA)] and l-[Co(EDTA)](-) across Caco-2 cell monolayers[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2008,29(7):1321-1324.
APA Mu, YP.,Wu, G.,Qiao, XW.,Gao, YX.,Zhou, LS.,...&高愈希.(2008).Transport and absorption of chiral metal complexes d-[Co(EDTA)] and l-[Co(EDTA)](-) across Caco-2 cell monolayers.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,29(7),1321-1324.
MLA Mu, YP,et al."Transport and absorption of chiral metal complexes d-[Co(EDTA)] and l-[Co(EDTA)](-) across Caco-2 cell monolayers".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 29.7(2008):1321-1324.
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