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Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis
Zhang J(张杰); Chen Q(陈启); Liu NQ(刘年庆); Li FL(李福亮); Zhang, J; Liu, Q; Chen, Q; Liu, NQ; Li, FL; Lu, ZB; Qin, C; Zhu, H; Huang, YY; He, W; Zhao, BL
2006
发表期刊FASEB JOURNAL
卷号20期号:8页码:1212-+
通讯作者Acad Sinica, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China ; Salk Inst Biol Studies, La Jolla, CA 92037 USA ; Acad Sinica, Lab Nucl Analyt Tech, Inst High Energy Phys, Beijing 100101, Peoples R China ; Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing 100037, Peoples R China ; Acad Sinica, Inst High Energy Phys, Sychrotron Radiat Lab, Beijing 100101, Peoples R China ; Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
文章类型Article
摘要Nicotine reduces beta-amyloidosis and has a beneficial effect against Alzheimer's disease (AD), but the underlying mechanism is not clear. The abnormal interactions of beta-amyloid (A beta) with metal ions such as copper and zinc are implicated in the process of A beta deposition in AD brains. In the present study, we investigated the effect of nicotine on metal homeostasis in the hippocampus and cortex of APP(V717I) ( London mutant form of APP) transgenic mice. A significant reduction in the metal contents of copper and zinc in senile plaques and neuropil is observed after nicotine treatment. The densities of copper and zinc distributions in a subfield of the hippocampus CA1 region are also reduced after nicotine treatment. We further studied the mechanism of nicotine-mediated effect on metal homeostasis by using SH-SY5Y cells overexpressing the Swedish mutant form of human APP (APPsw). Nicotine treatment decreases the intracellular copper concentration and attenuates A beta-mediated neurotoxicity facilitated by the addition of copper, and these effects are independent of the activation of nicotinic acetylcholine-receptor. These data suggest that the effect of nicotine on reducing beta-amyloidosis is partly mediated by regulating metal homeostasis.
关键词Alzheimer's disease A beta copper
学科领域Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology ; Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
DOI10.1096/fj.05-5214fje
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语种英语
研究领域[WOS]Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology ; Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
WOS类目Biochemistry & Molecular Biology ; Biology ; Cell Biology
WOS记录号WOS:000240210300029
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被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/239189
专题多学科研究中心
作者单位中国科学院高能物理研究所
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Zhang J,Chen Q,Liu NQ,et al. Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis[J]. FASEB JOURNAL,2006,20(8):1212-+.
APA 张杰.,陈启.,刘年庆.,李福亮.,Zhang, J.,...&Zhao, BL.(2006).Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.FASEB JOURNAL,20(8),1212-+.
MLA 张杰,et al."Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis".FASEB JOURNAL 20.8(2006):1212-+.
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