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[Gd@C-82(OH)(22)](n) Nanoparticles Induce Dendritic Cell Maturation and Activate Th1 Immune Responses
Yang, D; Zhao YL(赵宇亮); Xing GM(邢更妹); Zhao, YL; Guo, H; Li, YN; Tewary, P; Xing, GM; Hou, W; Oppenheim, JJ; Zhang, N
2010
发表期刊ACS NANO
卷号4期号:2页码:1178-1186
通讯作者[Yang, De ; Guo, Hua ; Hou, Wei ; Zhang, Ning] Tianjin Med Univ, Res Ctr Basic Med Sci, Canc Inst & Hosp, Key Lab Breast Canc Res,Minist Educ, Tianjin 300060, Peoples R China ; [Yang, De ; Li, Yana ; Tewary, Poonam ; Oppenheim, Joost J.] NCI, Basic Res Program, SAIC Frederick Inc,Ctr Canc Res, Lab Mol Immunoregulat,Canc & Inflammat Program, Frederick, MD 21702 USA ; [Zhao, Yuliang ; Xing, Gengmei] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China
摘要Dendritic cells play a pivotal role in host immune defense, such as elimination of foreign pathogen and inhibition of tumorigenesis. In this paper, we report that [Gd@C-82(OH)(22)](n) could induce phenotypic maturation of. dendritic cells by stimulating DC production of cytokines including IL-12p70, upregulating DC co-stimulatory (CD80, CD83, and CD86) and MHC (HLA-A,B,C and HLA-DR) molecules, and switching DCs from a CCL5-responsive to a CCL19-responsive phenotype. We found that [Gd@C-82(OH)(22)](n) can induce dendritic cells to become functionally mature as illustrated by their capacity to activate allogeneic T cells. Mice immunized with ovalbumin in the presence of [Gd@C-82(OH)(22)](n) exhibit enhanced ovalbumin-specific Th1-polarized immune response as evidenced by the predominantly increased production of IFN gamma, IL-1 beta, and IL-2. The [Gd@C-82(OH)(22)](n) nanoparticle is a potent activator of dendritic cells and Th1 immune responses. These new findings also provide a rational understanding of the potent anticancer activities of [Gd@C-82(OH)(22)](n) nanoparticles reported previously.
文章类型Article
关键词nanomedicine fullerene dendritic cells activation Th1 polarization
学科领域Chemistry; Science & Technology - Other Topics; Materials Science
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science
DOI10.1021/nn901478z
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语种英语
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号WOS:000274635800074
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被引频次:82[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/239146
专题多学科研究中心
加速器中心
作者单位中国科学院高能物理研究所
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Yang, D,Zhao YL,Xing GM,et al. [Gd@C-82(OH)(22)](n) Nanoparticles Induce Dendritic Cell Maturation and Activate Th1 Immune Responses[J]. ACS NANO,2010,4(2):1178-1186.
APA Yang, D.,赵宇亮.,邢更妹.,Zhao, YL.,Guo, H.,...&Zhang, N.(2010).[Gd@C-82(OH)(22)](n) Nanoparticles Induce Dendritic Cell Maturation and Activate Th1 Immune Responses.ACS NANO,4(2),1178-1186.
MLA Yang, D,et al."[Gd@C-82(OH)(22)](n) Nanoparticles Induce Dendritic Cell Maturation and Activate Th1 Immune Responses".ACS NANO 4.2(2010):1178-1186.
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