Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Anal Tech, Beijing 100049, Peoples R China
; Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
; Zhoukou Normal Univ, Dept Phys, Zhoukou 466100, Peoples R China
; Univ Texas, Hlth Sci Ctr, Res Imaging Ctr, San Antonio, TX 78229 USA
; Chinese Acad Sci, Inst Automat, Natl ASIC Design & Engn Ctr, Beijing 100049, Peoples R China
; Zhejiang Univ, Dept Phys, Hangzhou 310027, Peoples R China
The low signal to noise ratio (SNR) of functional MRI (fMRI) prefers more sensitive data analysis methods. Based oil stationary wavelet transform and Spectrum analysis, a new method with high detective sensitivity was developed for analyzing fMRI time series, which does not require any prior assumption of the characteristics of noises. In the proposed method, every component of fMRI time series in the different time-frequency scales of stationary wavelet transform was discerned by the spectrum analysis, then the components from noises were removed using the stationary wavelet transform, finally the components of real brain activation were detected by cross-correlation analysis. The results obtained front both simulated and in vivo visual experiments illustrated that the proposed method has much higher sensitivity than the traditional cross-correlation method.