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Mapping technique for biodistribution of elements in a model organism, Caenorhabditis elegans, after exposure to copper nanoparticles with microbeam synchrotron radiation X-ray fluorescence
Gao YX(高愈希); Liu NQ(刘年庆); Chen CY(陈春英); Li YF(李玉锋); Zhang ZY(张智勇); Zhao YL(赵宇亮); Chai ZF(柴之芳); Gao, Y; Liu, NQ; Chen, CY; Luo, YF; Li, YF; Zhang, ZY; Zhao, YL; Zhao, BL; Iida, A; Chai, ZF
刊名JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
2008
卷号23期号:8页码:1121-1124
学科分类Chemistry; Spectroscopy
DOI10.1039/b802338g
通讯作者[Gao, Yuxi ; Liu, Nianqing ; Chen, Chunying ; Li, Yufeng ; Zhang, Zhiyong ; Zhao, Yuliang ; Chai, Zhifang] Chinese Acad Sci, Bioenvironm Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Gao, Yuxi ; Liu, Nianqing ; Chen, Chunying ; Li, Yufeng ; Zhang, Zhiyong ; Zhao, Yuliang ; Chai, Zhifang] Chinese Acad Sci, Natl Ctr Nanosci & Technol China, Beijing 100049, Peoples R China ; [Luo, Yunfeng] Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China ; [Chen, Chunying] Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China ; [Iida, Atsuo] High Energy Accelerator Res Org, Photon Factory, Inst Mat Struct Sci, Tsukuba, Ibaraki 3050801, Japan
文章类型Article
英文摘要To investigate the toxicological effects of nanomaterials, experimental studies on the absorption and accumulation in organisms are of broad interest. In the present study, Caenorhabditis elegans (C. elegans) was used as a "model'' organism to investigate the bioaccumulation and toxicological effects of engineered copper nanoparticles with a scanning technique of microbeam synchrotron radiation X-ray fluorescence (m-SRXRF). The adult hermaphrodite is anatomically simple with 959 somatic cells and 1 mm in length. The mapping results of the whole organism indicate that the exposure to copper nanoparticles can result in an obvious elevation of Cu and K levels, and a change of bio-distribution of Cu in nematodes. Accumulation of Cu occurs in the head and at a location 1/3 of the way up the body from the tail compared to the un- exposed control. In contrast, a higher amount of Cu was detected in other portion of worm body, especially in its excretory cells and intestine when exposed to Cu(2+). The results compared well with total Cu levels in nematodes, which were 4.10 +/- 0.54, 12.32 +/- 0.49 and 5.22 +/- 0.63 mu g g(-1) dry weight for the PBS, Cu(2+) and Cu nanoparticle groups, respectively, measured by ICP- MS. The nondestructive and multi- elemental m- SRXRF provides an important tool for mapping the elemental distribution in the whole body of a single tiny nematode at lower levels.
类目[WOS]Chemistry, Analytical ; Spectroscopy
研究领域[WOS]Chemistry ; Spectroscopy
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语种英语
WOS记录号WOS:000257982600012
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被引频次:49[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/239081
专题院士_期刊论文
中国科学院高能物理研究所_实验物理中心
中国科学院高能物理研究所_加速器中心
中国科学院高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
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Gao YX,Liu NQ,Chen CY,et al. Mapping technique for biodistribution of elements in a model organism, Caenorhabditis elegans, after exposure to copper nanoparticles with microbeam synchrotron radiation X-ray fluorescence[J]. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY,2008,23(8):1121-1124.
APA 高愈希.,刘年庆.,陈春英.,李玉锋.,张智勇.,...&Chai, ZF.(2008).Mapping technique for biodistribution of elements in a model organism, Caenorhabditis elegans, after exposure to copper nanoparticles with microbeam synchrotron radiation X-ray fluorescence.JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY,23(8),1121-1124.
MLA 高愈希,et al."Mapping technique for biodistribution of elements in a model organism, Caenorhabditis elegans, after exposure to copper nanoparticles with microbeam synchrotron radiation X-ray fluorescence".JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY 23.8(2008):1121-1124.
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