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Analysis of mercury-containing protein fractions in brain cytosol of the maternal and infant rats after exposure to a low-dose of methylmercury by SEC coupled to isotope dilution ICP-MS
Wang M(王萌); Feng WY(丰伟悦); Wang HJ(王华建); Li B(李柏); Zhao YL(赵宇亮); Chai ZF(柴之芳); Wang, M; Feng, WY; Wang, HJ; Zhang, Y; Li, J; Li, B; Zhao, YL; Chai, ZF
2008
发表期刊JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
卷号23期号:8页码:1112-1116
通讯作者[Wang, Meng ; Feng, Wei-Yue ; Wang, Hua-Jian ; Li, Bai ; Zhao, Yu-Liang ; Chai, Zhi-Fang] Chinese Acad Sci, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [Wang, Meng ; Feng, Wei-Yue ; Wang, Hua-Jian ; Li, Bai ; Zhao, Yu-Liang ; Chai, Zhi-Fang] Chinese Acad Sci, Lab Bioenvironm Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Wang, Meng ; Wang, Hua-Jian ; Zhao, Yu-Liang] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China ; [Zhang, Yu] Jilin Univ, Sch Pharmaceut Sci, Changchun 130022, Peoples R China ; [Li, Jing] Capital Normal Univ, Coll Life Sci, Beijing 100037, Peoples R China
文章类型Article
摘要The mercury-containing protein fractions in the brain cytosol of the maternal and infant rats after exposure to low-dose of methylmercury chloride (0.3 mg Hg kg(-1) day(-1)) were analyzed by a SEC- ICPMS method with the postcolumn isotope dilution analysis. The enriched spiking including 34 S, 65 Cu, 67 Zn and 198 Hg was continuously added into the eluate from the HPLC column and then the isotopediluted fractions were on- line measured by ICP- MS. Therefore, the absolute amounts of sulfur, mercury, zinc and copper in the eluted protein fractions could be attained after calculation of the corresponding peak areas in the mass flow chromatogram. Five mercury- containing protein fractions were monitored in the maternal sample, whereas only one was in the infant sample. The mercury content in the infant sample was about 10 times lower than the one in the maternal sample. In the meantime, two copper- and four zinc- containing fractions were found in both maternal and infant samples. The detection limit for S, Cu, Zn and Hg are 11, 0.1, 1.5 and 0.2 ng, respectively. The results demonstrate that different mercury- containing protein fractions may exist in brain cytosol between maternal and infant rats and the quantitative calculation may be helpful for the toxicological study.
学科领域Chemistry; Spectroscopy
研究领域[WOS]Chemistry ; Spectroscopy ; Chemistry ; Spectroscopy
DOI10.1039/b802124d
URL查看原文
语种英语
研究领域[WOS]Chemistry ; Spectroscopy ; Chemistry ; Spectroscopy
WOS类目Chemistry, Analytical ; Spectroscopy
WOS记录号WOS:000257982600010
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被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/239066
专题院士
实验物理中心
加速器中心
多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Wang M,Feng WY,Wang HJ,et al. Analysis of mercury-containing protein fractions in brain cytosol of the maternal and infant rats after exposure to a low-dose of methylmercury by SEC coupled to isotope dilution ICP-MS[J]. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY,2008,23(8):1112-1116.
APA 王萌.,丰伟悦.,王华建.,李柏.,赵宇亮.,...&Chai, ZF.(2008).Analysis of mercury-containing protein fractions in brain cytosol of the maternal and infant rats after exposure to a low-dose of methylmercury by SEC coupled to isotope dilution ICP-MS.JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY,23(8),1112-1116.
MLA 王萌,et al."Analysis of mercury-containing protein fractions in brain cytosol of the maternal and infant rats after exposure to a low-dose of methylmercury by SEC coupled to isotope dilution ICP-MS".JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY 23.8(2008):1112-1116.
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