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Characterization of gold nanorods in vivo by integrated analytical techniques: their uptake, retention, and chemical forms
Wang, LM; Li YF(李玉锋); Li B(李柏); Chen CY(陈春英); Li, YF; Zhou, LJ; Liu, Y; Meng, L; Zhang, K; Wu, XC; Zhang, LL; Li, B; Chen, CY
2010
发表期刊ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷号396期号:3页码:1105-1114
通讯作者[Li, Yu-Feng ; Li, Bai ; Chen, Chunying] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [Wang, Liming ; Zhou, Liangjun ; Liu, Ying ; Meng, Li ; Zhang, Lili ; Chen, Chunying] Natl Ctr Nanosci & Technol China, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China ; [Zhang, Ke ; Wu, Xiaochun] Natl Ctr Nanosci & Technol China, Lab Nanoscale Measurement & Standardizat, Beijing 100190, Peoples R China
文章类型Article
摘要Integrated analytical techniques were used to study the tissue distribution and structural information of gold nanorods (Au NRs) in Sprague-Dawley rats through tail intravenous injection. Before in vivo experiments were conducted, careful characterization of Au NRs was performed. The zeta potential proved that adsorption of bovine serum albumin on Au NRs turned the surface charges from positive to negative as in an in vitro simulation. The biodistribution of Au NRs was investigated quantitatively by inductively coupled plasma mass spectrometry at different time points after injection. As target tissues, both liver and spleen were chosen to further demonstrate the intracellular localization of Au NRs by the combination of transmission electron microscopy and energy-dispersive X-ray spectroscopy. Moreover, synchrotron-radiation-based X-ray absorption spectroscopy was employed and it was observed that long-term retention of Au NRs in liver and spleen did not induce obvious changes in the oxidation states of gold. Therefore, the present systematic method can provide important information about the fates of Au NRs in vivo and can also be extended to study the biological effects of other metallic nanomaterials in the future.
关键词Gold nanorods Biodistribution Characterization in vivo Transmission electron microscopy Inductively coupled plasma mass spectrometry X-ray absorption spectroscopy
学科领域Biochemistry & Molecular Biology; Chemistry
DOI10.1007/s00216-009-3302-y
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语种英语
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemical Research Methods ; Chemistry, Analytical
WOS记录号WOS:000273845200016
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文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/239051
专题多学科研究中心
实验物理中心
加速器中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Wang, LM,Li YF,Li B,et al. Characterization of gold nanorods in vivo by integrated analytical techniques: their uptake, retention, and chemical forms[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2010,396(3):1105-1114.
APA Wang, LM.,李玉锋.,李柏.,陈春英.,Li, YF.,...&Chen, CY.(2010).Characterization of gold nanorods in vivo by integrated analytical techniques: their uptake, retention, and chemical forms.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,396(3),1105-1114.
MLA Wang, LM,et al."Characterization of gold nanorods in vivo by integrated analytical techniques: their uptake, retention, and chemical forms".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 396.3(2010):1105-1114.
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