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Molecular interaction between europium decatungstate and histone H1 and its application as a novel biological labeling agent
Zheng, L; Gu ZJ(谷战军); Gu, ZJ; Ma, Y; Zhang, GJ; Yao, JN; Keita, B; Nadjo, L
2010
发表期刊JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
卷号15期号:7页码:1079-1085
通讯作者[Zheng, Li ; Zhang, Guangjin] Chinese Acad Sci, Key Lab Green Proc Engn, Inst Proc Engn, Beijing 100190, Peoples R China ; [Zheng, Li ; Ma, Ying ; Yao, Jiannian] Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Photochem, Inst Chem, Beijing 100190, Peoples R China ; [Gu, Zhanjun] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Keita, Bineta ; Nadjo, Louis] Univ Paris 11, Chim Phys Lab, CNRS, UMR 8000, F-91405 Orsay, France ; [Zheng, Li] Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
文章类型Article
摘要Polyoxometalates (POMs) show promising biological activities, but the mechanism of potential therapeutic effects remains to be elucidated at a molecular level. As a step toward the elucidation of the mechanistic pathways governing the bioactivity of POMs, the interaction between Eu-containing decatungstate [EuW(10)O(36)](9-) (EuW10) and histone H1 has been studied. Fluorescence/luminescence analysis showed the existence of a strong interaction between EuW10 and histone H1. This interaction has key effects both on the luminescence of EuW10 and on the structure of histone H1. A gradual and intense enhancement of EuW10 luminescence was observed upon addition of increasing concentrations of histone H1. Circular dichroism investigations indicated that the binding of EuW10 significantly alters the secondary structure of histone H1. The present work is meaningful in finding novel labeling agents for fluorescence/luminescence or solid-state bioimaging.
关键词Lanthanide polyoxometalates Histone H1 Luminescence Fluorescence Molecular interaction Biolabel
学科领域Biochemistry & Molecular Biology; Chemistry
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Biochemistry & Molecular Biology ; Chemistry
DOI10.1007/s00775-010-0667-5
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语种英语
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear
WOS记录号WOS:000281597900009
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被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/239010
专题多学科研究中心
作者单位中国科学院高能物理研究所
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Zheng, L,Gu ZJ,Gu, ZJ,et al. Molecular interaction between europium decatungstate and histone H1 and its application as a novel biological labeling agent[J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,2010,15(7):1079-1085.
APA Zheng, L.,谷战军.,Gu, ZJ.,Ma, Y.,Zhang, GJ.,...&Nadjo, L.(2010).Molecular interaction between europium decatungstate and histone H1 and its application as a novel biological labeling agent.JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,15(7),1079-1085.
MLA Zheng, L,et al."Molecular interaction between europium decatungstate and histone H1 and its application as a novel biological labeling agent".JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 15.7(2010):1079-1085.
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