The effects of MESO-2,3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus
Zhang J(张杰); Wang XF(王雪飞); Liu NQ(刘年庆); Zhang, J; Wang, XF; Lu, ZB; Liu, NQ; Zhao, BL
刊名FREE RADICAL BIOLOGY AND MEDICINE
2004
卷号37期号:7页码:1037-1050
关键词antioxidant apoptosis chelating DMSA hippocampus lead neurotoxicity oxidative stress OPC free radicals
学科分类Biochemistry & Molecular Biology; Endocrinology & Metabolism
DOI10.1016/j.freeradbiomed.2004.06.037
通讯作者Acad Sinica, Inst Biophys, Ctr Brain & Cognit Sci, Lab Visual Informat Proc, Beijing 100101, Peoples R China ; Acad Sinica, Inst High Energy Phys, Beijing 100039, Peoples R China
文章类型Article
英文摘要Oxidative stress is considered to be a mechanism involved in lead neurotoxicity. Apoptosis is also thought to relate to lead neurotoxicity. The present study, focused on the hippocampus, was designed to investigate the two possible mechanisms involved in lead neurotoxicity and the potential protective effects of 2,3-dimercaptosuccinic acid (DMSA) and oligomeric procyanidins (OPC). It was proved that reactive oxygen species and oxidative damage were implicated in the induction of apoptosis induced by lead in the hippocampus. Administration of DMSA attenuated the oxidative stress and apoptosis in addition to having strong chelating and lead-removing capacity. OPC alone had antioxidant protective effects in the hippocampus but no removing capacity for lead in vivo despite showing higher affinity and stronger chelating ability for Pb2+ than DMSA in vitro. It is suggested that OPC chelates Pb2+ but does not discharge it from the body and even accumulates Pb2+ in some organs. At the same time, a reasonable deduction can also be made that the complex of OPC-Pb2+ prevents or at least weakens the neurotoxicity of Pb2+. Whether this complex displays toxicity over a long time span should be studied further. (C) 2004 Elsevier Inc. All rights reserved.
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
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语种英语
WOS记录号WOS:000224011900015
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被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/238936
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
作者单位中国科学院高能物理研究所
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Zhang J,Wang XF,Liu NQ,et al. The effects of MESO-2,3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus[J]. FREE RADICAL BIOLOGY AND MEDICINE,2004,37(7):1037-1050.
APA 张杰.,王雪飞.,刘年庆.,Zhang, J.,Wang, XF.,...&Zhao, BL.(2004).The effects of MESO-2,3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus.FREE RADICAL BIOLOGY AND MEDICINE,37(7),1037-1050.
MLA 张杰,et al."The effects of MESO-2,3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus".FREE RADICAL BIOLOGY AND MEDICINE 37.7(2004):1037-1050.
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