White-matter Volume Reduction and the Protective Effect of Immunosuppressive Therapy in Systemic Lupus Erythematosus Patients with Normal Appearance by Conventional Magnetic Resonance Imaging
Xu, J; Cheng, YQ; Chai P(柴培); Li L(李琳); Dan BC(单保慈); Chai, P; Lu, ZP; Li, HJ; Luo, CR; Li, XZ; Li, L; Zhou, QX; Chen, B; Cao, J; Xu, XF; Shan, B; Xu, L; Wen, JF
刊名JOURNAL OF RHEUMATOLOGY
2010
卷号37期号:5页码:974-986
关键词WHITE MATTER SYSTEMIC LUPUS ERYTHEMATOSUS IMMUNOSUPPRESSIVE THERAPY MAGNETIC RESONANCE IMAGING
学科分类Rheumatology
DOI10.3899/jrheum.090967
通讯作者[Chen, Bing ; Wen, Jianfan] Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China ; Chinese Acad Sci, Grad Sch, Beijing, Peoples R China ; [Zhou, Qixin ; Cao, Jun] Chinese Acad Sci, Key Lab Anim Models & Human Dis Mechanisms, Kunming 650223, Yunnan, Peoples R China ; [Xu, Jian ; Li, Xizhi] Kunming Med Coll, Affiliated Hosp 1, Dept Rheumatol & Immunol, Kunming, Peoples R China ; [Xu, Xiufeng] Kunming Med Coll, Affiliated Hosp 1, Dept Psychiat, Kunming, Peoples R China ; [Chai, Pei ; Li, Lin ; Shan, Baoci] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Anal, Beijing, Peoples R China ; [Luo, Chunrong] First Hosp Kunming City, Magnet Resonance Imaging Ctr, Kunming, Yunnan, Peoples R China
文章类型Article
英文摘要Objective. The central nervous system (CNS) is often affected by systemic lupus erythematosus (SLE), but assessment of CNS outcomes using noninvasive cerebral structural measures remains in its infancy. Magnetic resonance imaging (MRI) with expert visual interpretation is critical to diagnosis, but does not permit quantitative measurements. Our pilot study investigated whether quantitative brain volumetric analyses could be used to detect white-matter (WM) abnormalities and responses to treatment in SLE (ClinicalTrials.gov: NCT00703742). Methods. Forty-two pairs of SLE patients and healthy controls underwent high-resolution 3-dimensional structural MRI scans. Combining voxel-based morphometry and region of interest analyses, subtle WM volume abnormalities in whole brains from SLE patients were identified, and regional WM volume was calculated. Associations between WM volume and symptom severity, as well as the effects of immunosuppressive therapy, were then investigated. Results. The WM volume of the SLE group was significantly decreased in the bilateral posterior and anterior crus of the internal capsule (PIC and AIC, respectively), the subgyral right frontal lobe, and left temporal lobe (p<0.001). Regional WM volume (left PIC and right AIC) was correlated with SLEDAI scores. The WM volume of patients treated with immunosuppressive therapy was greater than that of patients who were never treated with immunosuppressive therapy. Conclusion. Quantitative brain volumetric analyses detect brain injuries in WM for SLE that are not obvious by conventional MRI, and may be adequately sensitive and quantitative to measure the effect of therapeutic interventions M preventing brain injury and outcomes in SLE. (First Release March 15 2010; J Rheumatol 2010;37:974-86; doi:10.3899/jrheum.090967)
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
原文出处查看原文
语种英语
WOS记录号WOS:000277696700017
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/238824
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_实验物理中心
中国科学院高能物理研究所_粒子天体物理中心
中国科学院高能物理研究所_中国散裂中子源
中国科学院高能物理研究所_核技术应用研究中心
作者单位中国科学院高能物理研究所
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Xu, J,Cheng, YQ,Chai P,et al. White-matter Volume Reduction and the Protective Effect of Immunosuppressive Therapy in Systemic Lupus Erythematosus Patients with Normal Appearance by Conventional Magnetic Resonance Imaging[J]. JOURNAL OF RHEUMATOLOGY,2010,37(5):974-986.
APA Xu, J.,Cheng, YQ.,柴培.,李琳.,单保慈.,...&Wen, JF.(2010).White-matter Volume Reduction and the Protective Effect of Immunosuppressive Therapy in Systemic Lupus Erythematosus Patients with Normal Appearance by Conventional Magnetic Resonance Imaging.JOURNAL OF RHEUMATOLOGY,37(5),974-986.
MLA Xu, J,et al."White-matter Volume Reduction and the Protective Effect of Immunosuppressive Therapy in Systemic Lupus Erythematosus Patients with Normal Appearance by Conventional Magnetic Resonance Imaging".JOURNAL OF RHEUMATOLOGY 37.5(2010):974-986.
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