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Trace Metal Disturbance in Mice Brain after Intranasal Exposure of Nano- and Submicron-Sized Fe2O3 Particles
Wang B(汪冰); Wang Y(王云); Feng WY(丰伟悦); Zhu MT(朱墨桃); Wang M(王萌); Ou YH(欧阳宏); Wang HJ(王华建); Li M(李明); Zhao YL(赵宇亮); Chai ZF(柴之芳); Wang, B; Wang, Y; Feng, WY; Zhu, MT; Wang, M; Ouyang, H; Wang, HJ; Li, M; Zhao, YL; Chai, ZF
2008
发表期刊CHEMIA ANALITYCZNA
卷号53期号:6页码:927-942
通讯作者[Wang, Bing ; Wang, Yun ; Feng, Weiyue ; Zhu, Motao ; Wang, Meng ; Ouyang, Hong ; Wang, Huajian ; Li, Ming ; Zhao, Yuliang ; Chai, Zhifang] Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Wang, Bing ; Wang, Yun ; Feng, Weiyue ; Zhu, Motao ; Wang, Meng ; Ouyang, Hong ; Wang, Huajian ; Li, Ming ; Zhao, Yuliang ; Chai, Zhifang] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [Wang, Yun ; Zhu, Motao ; Wang, Meng ; Wang, Huajian ; Li, Ming] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
文章类型Article
摘要Trace metals in the brain play an important role in the Function of central nervous system (CNS). The objective of this work is to investigate the effects of intranasal exposure Of nano- and submicron-sized Fe2O3 particles on the homeostasis of trace metals ill the brain. After a single intranasal instillation of nano- and submicron-sized Fe2O3 particles, the contents of Fe, Cu and Zn in the sub-brain regions were determined in the time course from 4 h till to the 30 day post-exposure. Our results indicated that the imbalance of trace metals in the sub-brain regions of mice was induced by the two sizes of Fe2O3 particles. The more significant accumulation of Fe in the brain was found in the nano-Fe2O3 treated mice than in the submicron-Fe2O3 treated ones; meanwhile, similar alterations of Zn contents in the brain were observed as well. A strong positive correlation between Fe and Zn levels in the olfactory bulb of nano-Fe2O3 instilled mice and in the hippocampus and cerebral cortex of submicron-Fe2O3 instilled mice were found. This is the first trial to investigate the disturbance of trace metals in the brain after exposure to Fe2O3 nanoparticles. These results state that much attention should be paid to the potential impact of inhaled Fe2O3 nanoparticles on the CNS.
关键词Fe2O3 nanoparticles Trace metals in mice brain Cu, Zn ICP-MS NAA
学科领域Chemistry
研究领域[WOS]Chemistry ; Chemistry
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语种英语
研究领域[WOS]Chemistry ; Chemistry
WOS类目Chemistry, Analytical
WOS记录号WOS:000262975600015
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/238752
专题院士
加速器中心
粒子天体物理中心
多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Wang B,Wang Y,Feng WY,et al. Trace Metal Disturbance in Mice Brain after Intranasal Exposure of Nano- and Submicron-Sized Fe2O3 Particles[J]. CHEMIA ANALITYCZNA,2008,53(6):927-942.
APA 汪冰.,王云.,丰伟悦.,朱墨桃.,王萌.,...&Chai, ZF.(2008).Trace Metal Disturbance in Mice Brain after Intranasal Exposure of Nano- and Submicron-Sized Fe2O3 Particles.CHEMIA ANALITYCZNA,53(6),927-942.
MLA 汪冰,et al."Trace Metal Disturbance in Mice Brain after Intranasal Exposure of Nano- and Submicron-Sized Fe2O3 Particles".CHEMIA ANALITYCZNA 53.6(2008):927-942.
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