Multi-Center Study on Alzheimer's Disease Using FDG PET: Group and Individual Analyses
Yuan XL(袁秀丽); Dan BC(单保慈); Yuan, XL; Shan, BC; Ma, YC; Tian, JH; Jiang, KD; Cao, QY; Wang, RM
刊名JOURNAL OF ALZHEIMERS DISEASE
2010
卷号19期号:3页码:927-935
关键词Alzheimer's disease hypo-metabolism individual analysis multicenter study positron emission tomography
学科分类Neurosciences & Neurology
DOI10.3233/JAD-2010-1287
通讯作者[Yuan, Xiuli ; Shan, Baoci] Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Ma, Yunchuan] Capital Univ Med Sci, Xuanwu Hosp, PET Ctr, Beijing, Peoples R China ; [Tian, Jiahe ; Wang, Ruimin] Gen Hosp PLA, Dept Nucl Med, Beijing, Peoples R China ; [Jiang, Kaida ; Cao, Qiuyun] Mental Hlth Ctr Shanghai, Shanghai, Peoples R China
文章类型Article
英文摘要Using statistical parametric mapping (SPM), we evaluate the feasibility and accuracy of (18)F-2-deoxy-2-fluoro-Dglucose (FDG) positron emission tomography (PET) for clinical diagnosis with characteristic hypo-metabolic regions, and examine the consistency of cerebral hypo-metabolism in Alzheimer's disease (AD) cross multicenters at both the group and the individual levels. Four groups of scan data including 39 AD patients and 52 healthy control subjects derived from three centers were analyzed and comparisons between patient subgroups or individual patient and relevant control population were performed using Two Sample T-test. In the group analysis, the hypo-metabolic regions of AD patients obtained from different PET centers were similar and consistent. The common hypo-metabolic cerebral areas were located bilaterally in the posterior cingulate and medial parietal cortex, temporo-parietal cortex, prefrontal cortex, and the middle and inferior temporal gyrus (uncorrected, p < 0.001). In the analysis of each individual subject, the location of declined posterior cingulate and medial parietal cortex, temporo-parietal cortex and temporal lobe were found highly consistent with relevant characteristic regions obtained in the group analysis and were selected for diagnosic purposes. Complete typical hypo-metabolic pattern was observed in 67% and 54% of AD patients in two sets of 3D scans, respectively. Only 27% and 33.3% patients showed full typical pattern in two sets of 2D scans. The results indicated that FDG PET measures and SPM can provide a valuable reference for clinical diagnosis of AD patients. The potential influence of acquisition mode on the clinical diagnosis of AD was suggested for further evaluation.
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
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语种英语
WOS记录号WOS:000276617100014
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被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/238751
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
作者单位中国科学院高能物理研究所
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Yuan XL,Dan BC,Yuan, XL,et al. Multi-Center Study on Alzheimer's Disease Using FDG PET: Group and Individual Analyses[J]. JOURNAL OF ALZHEIMERS DISEASE,2010,19(3):927-935.
APA 袁秀丽.,单保慈.,Yuan, XL.,Shan, BC.,Ma, YC.,...&Wang, RM.(2010).Multi-Center Study on Alzheimer's Disease Using FDG PET: Group and Individual Analyses.JOURNAL OF ALZHEIMERS DISEASE,19(3),927-935.
MLA 袁秀丽,et al."Multi-Center Study on Alzheimer's Disease Using FDG PET: Group and Individual Analyses".JOURNAL OF ALZHEIMERS DISEASE 19.3(2010):927-935.
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