IHEP OpenIR  > 院士  > 期刊论文
Antioxidative function and biodistribution of [Gd@C-82(OH)(22)](n) nanoparticles in tumor-bearing mice
Wang JX(王江雪); Chen CY(陈春英); Li B(李柏); Yu HW(喻宏伟); Zhao YL(赵宇亮); Sun J(孙瑾); Li YF(李玉锋); Xing GM(邢更妹); Yuan H(袁慧); Tang J(唐军); Chen Z(陈真); Meng H(孟浩); Gao YX(高愈希); Ye C(叶昶); Chai ZF(柴之芳); Wang, JX; Chen, CY; Li, B; Yu, HW; Zhao, YL; Sun, J; Li, YF; Xing, GM; Yuan, H; Tang, J; Chen, Z; Meng, H; Gao, YX; Ye, C; Chai, ZF; Zhu, CF; Ma, BC; Fang, XH; Wan, LJ
刊名BIOCHEMICAL PHARMACOLOGY
2006
卷号71期号:6页码:872-881
关键词[Gd@C-82(OH)(22)](n) nanoparticles oxidative stress antioxidant biodistribution in vivo
学科分类Pharmacology & Pharmacy
DOI10.1016/j.bcp.2005.12.001
通讯作者Chinese Acad Sci, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100049, Peoples R China ; Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China ; Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China
文章类型Article
英文摘要Oxidative stress is considered to be one of the important mechanisms involved in carcinogenesis. In our previous study, gadolinium endohedral metallofullerenol ([Gd@C-82(OH)(22)](n) nanoparticles) have shown high inhibitory activity on hepatoma cell (H22) growth in mice. To explore the antioxidative functions of nanoparticles, we investigated the biodistribution of [Gd@C-82(OH)(22)](n) nanoparticles, the changes of blood coagulation profiles, the metabolism of reactive oxygen species (ROS) in the tumor-bearing mice as well as the possible relationships between nanoparticles treatment and ROS production in this paper. The activities of hepatic superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione S-transferase (GST) and catalase (CAT) as well as the levels of reduced glutathione (GSH), protein-bound thiols and malondialdehyde (MDA) were compared between the tumor-bearing mice and normal mice. Transplanted tumors were grown in mice by subcutaneous injection of murine hepatoma cells in the mice. The comparison of the above parameters between nanoparticles and cyclophosphamide (CTX) therapy were also investigated. [Gd@C-82(OH)(22)](n). administration can efficiently restore the damaged liver and kidney of the tumor-bearing mice. All the activities of enzymes and other parameters related to oxidative stress were reduced after [Gd@C-82(OH)(22)](n) treatment and tended closely to the normal levels. The results suggest that [Gd@C-82(OH)(22)](n) nanoparticle treatment could regulate ROS production in vivo. (c) 2005 Elsevier Inc. All rights reserved.
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
原文出处查看原文
语种英语
WOS记录号WOS:000235723100018
引用统计
被引频次:117[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/238648
专题院士_期刊论文
中国科学院高能物理研究所_实验物理中心
中国科学院高能物理研究所_加速器中心
中国科学院高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714
Wang JX,Chen CY,Li B,et al. Antioxidative function and biodistribution of [Gd@C-82(OH)(22)](n) nanoparticles in tumor-bearing mice[J]. BIOCHEMICAL PHARMACOLOGY,2006,71(6):872-881.
APA 王江雪.,陈春英.,李柏.,喻宏伟.,赵宇亮.,...&Wan, LJ.(2006).Antioxidative function and biodistribution of [Gd@C-82(OH)(22)](n) nanoparticles in tumor-bearing mice.BIOCHEMICAL PHARMACOLOGY,71(6),872-881.
MLA 王江雪,et al."Antioxidative function and biodistribution of [Gd@C-82(OH)(22)](n) nanoparticles in tumor-bearing mice".BIOCHEMICAL PHARMACOLOGY 71.6(2006):872-881.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
5625.pdf(566KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[王江雪]的文章
[陈春英]的文章
[李柏]的文章
百度学术
百度学术中相似的文章
[王江雪]的文章
[陈春英]的文章
[李柏]的文章
必应学术
必应学术中相似的文章
[王江雪]的文章
[陈春英]的文章
[李柏]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 5625.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。