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Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy
Wang, LM; Liu, Y; Li W(李炜); Li YF(李玉锋); Zhao YL(赵宇亮); Chen CY(陈春英); Li, W; Jiang, XM; Ji, YL; Wu, XC; Xu, LG; Qiu, Y; Zhao, K; Wei, TT; Li, YF; Zhao, YL; Chen, CY
2011
发表期刊NANO LETTERS
卷号11期号:2页码:772-780
通讯作者[Ji, Yinglu ; Wu, Xiaochun] Natl Ctr Nanosci & Technol China, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China ; [Wang, Liming ; Liu, Ying ; Jiang, Xiumei ; Xu, Ligeng ; Qiu, Yang ; Chen, Chunying] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China ; [Li, Wei ; Li, Yufeng ; Zhao, Yuliang ; Chen, Chunying] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Li, Wei ; Li, Yufeng ; Zhao, Yuliang ; Chen, Chunying] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [Zhao, Kai ; Wei, Taotao] Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China
文章类型Article
摘要We have observed that Au nanorods (NRs) have distinct effects on cell viability via killing cancer cells while posing negligible impact on normal cells and mesenchymal stem cells. Obvious differences in cellular uptake, intracellular trafficking, and susceptibility of lysosome to Au NRs by different types of cells resulted in selective accumulation of Au NRs in the mitochondria of cancer cells. Their long-term retention decreased mitochondrial membrane potential and increased reactive oxygen species level that enhances the likelihood of cell death. These findings thus provide guidance for the design of organelle-targeted nanomaterials in tumor therapy.
关键词Gold nanorods serum proteins uptake and removal intracellular localization mitochondrion-targeted nanomaterials tumor therapy
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics ; Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
DOI10.1021/nl103992v
URL查看原文
语种英语
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics ; Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号WOS:000287049100078
引用统计
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/238461
专题多学科研究中心
实验物理中心
加速器中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Wang, LM,Liu, Y,Li W,et al. Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy[J]. NANO LETTERS,2011,11(2):772-780.
APA Wang, LM.,Liu, Y.,李炜.,李玉锋.,赵宇亮.,...&Chen, CY.(2011).Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy.NANO LETTERS,11(2),772-780.
MLA Wang, LM,et al."Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy".NANO LETTERS 11.2(2011):772-780.
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