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Increased oxidative DNA damage, as assessed by urinary 8-hydroxy-2 '-deoxyguanosine concentrations, and serum redox status in persons exposed to mercury
Chen CY(陈春英); Li B(李柏); Xing, Li; Gao YX(高愈希); Zhang PQ(章佩群); Li M(李萌); Chai ZF(柴之芳); Chen, CY; Qu, LY; Li, B; Xing, L; Jia, G; Wang, TC; Gao, YX; Zhang, PQ; Li, M; Chen, W; Chai, ZF
2005
发表期刊CLINICAL CHEMISTRY
卷号51期号:4页码:759-767
通讯作者Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; Chinese Acad Sci, Inst High Energy Phys, Lab Nanoscale Mat & Related Bioenvironm Sci, Beijing 100049, Peoples R China ; Guizhou Res & Design Inst Environm Sci, Guiyang, Peoples R China ; Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Beijing 100871, Peoples R China ; Peking Univ, Hosp 3, Dept Clin Lab, Beijing 100871, Peoples R China
摘要Background: Mercury is a ubiquitous and highly toxic environmental pollutant. In this study, we evaluated the relationship between mercury exposure and oxidative stress, serum and urinary mercury concentrations, oxidative DNA damage, and serum redox status in chronically mercury-exposed persons compared with healthy controls. Methods: We measured urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), which we used as a biomarker of oxidative DNA damage in the mercury-exposed persons, by HPLC with electrochemical detection (ECD). We evaluated antioxidant status by measuring the activities of superoxide dismutase and glutathione peroxidase and the concentrations of total reduced glutathione and protein-bound thiols in serum. Results: The significant increase in 8-OHdG concentrations in urine indicated that mercury-induced oxidative damage to DNA occurred in vivo. Differences in body mercury burden and antioxidant enzyme activities were statistically significant between the mercury-exposed persons and controls. Serum and urinary mercury concentrations in the mercury-exposed persons were more than 40-fold higher than in controls. Conclusions: Mercury exposure can induce oxidative DNA damage, whereas the antioxidative repair systems can be expected to minimize DNA lesions caused by mercury. Measurement of urinary 8-OHdG could be useful for evaluating in vivo oxidative DNA damage in mercury-exposed populations. (c) 2005 American Association for Clinical Chemistry.
文章类型Article
学科领域Medical Laboratory Technology
研究领域[WOS]Medical Laboratory Technology
DOI10.1373/clinchem.2004.042093
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语种英语
WOS类目Medical Laboratory Technology
WOS记录号WOS:000227936600011
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被引频次:71[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/238434
专题院士
实验物理中心
多学科研究中心
作者单位中国科学院高能物理研究所
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Chen CY,Li B,Xing, Li,et al. Increased oxidative DNA damage, as assessed by urinary 8-hydroxy-2 '-deoxyguanosine concentrations, and serum redox status in persons exposed to mercury[J]. CLINICAL CHEMISTRY,2005,51(4):759-767.
APA 陈春英.,李柏.,Xing, Li.,高愈希.,章佩群.,...&Chai, ZF.(2005).Increased oxidative DNA damage, as assessed by urinary 8-hydroxy-2 '-deoxyguanosine concentrations, and serum redox status in persons exposed to mercury.CLINICAL CHEMISTRY,51(4),759-767.
MLA 陈春英,et al."Increased oxidative DNA damage, as assessed by urinary 8-hydroxy-2 '-deoxyguanosine concentrations, and serum redox status in persons exposed to mercury".CLINICAL CHEMISTRY 51.4(2005):759-767.
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