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Biopharmaceutics and Therapeutic Potential of Engineered Nanomaterials
Liang, XJ; Chen CY(陈春英); Zhao YL(赵宇亮); Chen, CY; Zhao, YL; Jia, L; Wang, PC
2008
发表期刊CURRENT DRUG METABOLISM
卷号9期号:8页码:697-709
通讯作者[Liang, Xing-Jie ; Chen, Chunying ; Zhao, Yuliang] Natl Ctr Nanosci & Technol China, Div Nanomed & Nanobiol, Lab Nanobiomed & Nanosafety, Beijing, Peoples R China ; [Chen, Chunying ; Zhao, Yuliang] Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Jia, Lee] NCI, Toxicol & Pharmacol Branch, Div Canc Treatment & Diag, NIH, Rockville, MD 20852 USA ; [Wang, Paul C.] Howard Univ, Dept Radiol, Lab Mol Imaging, Washington, DC 20060 USA
文章类型Review
摘要Engineered nanomaterials are at the leading edge of the rapidly developing nanosciences and are founding an important class of new materials with specific physicochemical properties different from bulk materials with the same compositions. The potential for nanomaterials is rapidly expanding with novel applications constantly being explored in different areas. The unique size-dependent properties of nanomaterials make them very attractive for pharmaceutical applications. Investigations of physical, chemical and biological properties of engineered nanomaterials have yielded valuable information. Cytotoxic effects of certain engineered nanomaterials towards malignant cells form the basis for one aspect of nanomedicine. It is inferred that size, three dimensional shape, hydrophobicity and electronic configurations make them an appealing subject in medicinal chemistry. Their unique structure coupled with immense scope for derivatization forms a base for exciting developments in therapeutics. This review article addresses the fate of absorption, distribution, metabolism and excretion (ADME) of engineered nanoparticles in vitro and in vivo. It updates the distinctive methodology used for studying the biopharmaceutics of nanoparticles. This review addresses the future potential and safety concerns and genotoxicity of nanoparticle formulations in general. It particularly emphasizes the effects of nanoparticles on metabolic enzymes as well as the parenteral or inhalation administration routes of nanoparticle formulations. This paper illustrates the potential of nanomedicine by discussing biopharmaceutics of fullerene derivatives and their suitability for diagnostic and therapeutic purposes. Future direction is discussed as well.
关键词Metabolism engineered nanomaterials nanomedicine fullerenol carbon nanotube titanium dioxide (TiO2) silica dioxide (SiO2) magnetic nanoparticles
学科领域Biochemistry & Molecular Biology; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
DOI10.2174/138920008786049230
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语种英语
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS类目Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS记录号WOS:000260015100003
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被引频次:70[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/238299
专题多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Liang, XJ,Chen CY,Zhao YL,et al. Biopharmaceutics and Therapeutic Potential of Engineered Nanomaterials[J]. CURRENT DRUG METABOLISM,2008,9(8):697-709.
APA Liang, XJ.,陈春英.,赵宇亮.,Chen, CY.,Zhao, YL.,...&Wang, PC.(2008).Biopharmaceutics and Therapeutic Potential of Engineered Nanomaterials.CURRENT DRUG METABOLISM,9(8),697-709.
MLA Liang, XJ,et al."Biopharmaceutics and Therapeutic Potential of Engineered Nanomaterials".CURRENT DRUG METABOLISM 9.8(2008):697-709.
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