Element analysis in femur of diabetic osteoporosis model by SRXRF microprobe
Fei, YR; Zhang, M; Li, M; Huang, YY; He, W; Ding, WJ; Yang, JH; Huang YY(黄宇营); He W(何伟)
刊名MICRON
2007
卷号38期号:6页码:637-642
关键词osteoporosis diabetes element analysis synchrotron radiation X-ray fluorescence microbe
学科分类Microscopy
DOI10.1016/j.micron.2006.09.003
通讯作者Grad Univ, Chinese Acad Sci, Dept Biol, Beijing 100049, Peoples R China ; Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Facil, Beijing 100049, Peoples R China
文章类型Review
英文摘要Diabetes mellitus affects bone metabolism and leads to osteopenia and osteoporosis, but its pathogenic mechanism remains unknown. To address this problem, mineral element of bone was analyzed in experimental diabetic osteoporosis model. Male Wistar rats were randomly divided into streptozotocin (STZ)-induced diabetic group (n = 5) and control group (n = 5). The experiment lasted 68 days and at the end of the experiment, femoral bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry and element content in femur of animals was determined by synchrotron radiation X-ray fluorescence (SRXRF) microprobe analysis technique. Results showed that femoral BMD in diabetic group was significantly lower than that in control (P < 0.01). Relative mineral content of calcium (Ca), phosphor-us (P) and zinc (Zn) in diabetic femurs decreased significantly compared to controls. And strontium (Sr) in diabetics reduced 11% (P = 0.09). Relative content of sulfur(S) in average was statistically higher (P < 0.01) in diabetics than that in controls. But no obvious difference was observed in relative content of chromium (Cr), iron (Fe), copper (Cu), and lead (Ph) between the two groups. Statistical analysis revealed that Ca correlated positively with P (R = 0.85 and P < 0.001), with Sr (R = 0.38 and P < 0.05) and with Zn (R = 0.37 and P < 0.05). Whereas, Zn correlated negatively with S (R = -0.40 and P < 0.05). Our results reveal that loss of minerals accounts for the BMD reduction in diabetics. (C) 2006 Elsevier Ltd. All rights reserved.
类目[WOS]Microscopy
研究领域[WOS]Microscopy
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语种英语
WOS记录号WOS:000246629400013
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被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/238164
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
作者单位中国科学院高能物理研究所
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Fei, YR,Zhang, M,Li, M,et al. Element analysis in femur of diabetic osteoporosis model by SRXRF microprobe[J]. MICRON,2007,38(6):637-642.
APA Fei, YR.,Zhang, M.,Li, M.,Huang, YY.,He, W.,...&何伟.(2007).Element analysis in femur of diabetic osteoporosis model by SRXRF microprobe.MICRON,38(6),637-642.
MLA Fei, YR,et al."Element analysis in femur of diabetic osteoporosis model by SRXRF microprobe".MICRON 38.6(2007):637-642.
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