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Accumulation of mercury, selenium and their binding proteins in porcine kidney and liver from mercury-exposed areas with the investigation of their redox responses
Chen CY(陈春英); Zhao JJ(赵九江); Deng GL(邓桂龙); Li B(李柏); Zhang PQ(章佩群); Chai ZF(柴之芳); Chen, CY; Qu, LY; Zhao, JJ; Liu, SP; Deng, GL; Li, B; Zhang, PQ; Chai, ZF
刊名SCIENCE OF THE TOTAL ENVIRONMENT
2006
卷号366期号:2-3页码:627-637
关键词mercury selenium liver kidney metallothionein redox status
学科分类Environmental Sciences & Ecology
DOI10.1016/j.scitotenv.2005.12.021
通讯作者Chinese Acad Sci, Key Lab Nucl Analyt Tech, Beijing 100039, Peoples R China ; Chinese Acad Sci, Inst High Energy Phys, Beijing 100039, Peoples R China ; Guizhou Res & Designing Inst Environm Sci, Guiyang 550002, Peoples R China ; Wanshan Off Environm Protect, Guizhou, Peoples R China
文章类型Article
英文摘要The subcellular localization of Se and Hg and their cytosolic binding proteins, including cellular oxidative status, in porcine liver and kidney have been studied by using samples from a chronic Hg-contaminated area and a non-Hg-contaminated area. Coaccumulation and redistribution of Se and Hg in subcellular fractions due to mercury exposure were found. The Hg and Se concentrations in tissues from Hg-exposed porcine were 80 folds and 5-20 folds higher than controls, respectively. Insterestingly, the retention of both Se and Hg increased 10% in mitochondria, while decreased 10% in cytosol of Hg-exposed pig liver. Mercury was mainly in the form of MTs in the cytosol of the non-Hg-exposed porcine kidney. NIT binds Hg in the cytosol with limited capacity, and the rest Hg was redistributed to the high molecular weight (MW) proteins (80-100 kDa) in the Hg-exposed group. The coaccumulation of Hg and Se was also found in high MW proteins, where their molar ratio was tended to be 1: 1. Moreover, the Se-containing polypeptides (3-6 kDa) increased significantly both in hepatic and renal cytosol of the Hg-exposed pigs. Se-dependent GSH-Px and SOD activity were increased to cope with Hg-induced oxidative stress. In previous studies, the roles of Se and MTs were generally taken into account separately; we discussed their combining roles in the case of high Hg exposure. The present results were beneficial to understand the existing states of Hg in vivo and evaluate the interaction of toxic and essential elements. (c) 2006 Elsevier B.V. All rights reserved.
类目[WOS]Environmental Sciences
研究领域[WOS]Environmental Sciences & Ecology
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语种英语
WOS记录号WOS:000239877400019
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被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/238143
专题院士_期刊论文
中国科学院高能物理研究所_实验物理中心
中国科学院高能物理研究所_多学科研究中心
中国科学院高能物理研究所_中国散裂中子源
作者单位中国科学院高能物理研究所
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GB/T 7714
Chen CY,Zhao JJ,Deng GL,et al. Accumulation of mercury, selenium and their binding proteins in porcine kidney and liver from mercury-exposed areas with the investigation of their redox responses[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2006,366(2-3):627-637.
APA 陈春英.,赵九江.,邓桂龙.,李柏.,章佩群.,...&Chai, ZF.(2006).Accumulation of mercury, selenium and their binding proteins in porcine kidney and liver from mercury-exposed areas with the investigation of their redox responses.SCIENCE OF THE TOTAL ENVIRONMENT,366(2-3),627-637.
MLA 陈春英,et al."Accumulation of mercury, selenium and their binding proteins in porcine kidney and liver from mercury-exposed areas with the investigation of their redox responses".SCIENCE OF THE TOTAL ENVIRONMENT 366.2-3(2006):627-637.
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