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The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials
Yin, JJ; Lao, F; Fu, PP; Wamer, WG; Zhao, YL; Wang, PC; Qiu, Y; Sun, BY; Xing, GM; Dong, JQ; Liang, XJ; Chen, CY; Zhao YL(赵宇亮); Sun BY(孙宝云); Xing GM(邢更妹); Dong JQ(董金泉); Chen CY(陈春英)
2009
发表期刊BIOMATERIALS
卷号30期号:4页码:611-621
通讯作者[Lao, Fang ; Zhao, Yuliang ; Qiu, Yang ; Liang, Xing-Jie ; Chen, Chunying] Natl Ctr Nanosci & Technol China, Div Nanomed & Nanobiol, Beijing 100190, Peoples R China ; [Yin, Jun-Jie ; Wamer, Wayne G.] US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD 20740 USA ; [Zhao, Yuliang ; Sun, Baoyun ; Xing, Gengmei ; Dong, Jinquan ; Chen, Chunying] Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Fu, Peter P.] US FDA, Natl Ctr Toxicol Res, Div Biochem Toxicol, Jefferson, AR 72079 USA ; [Wang, Paul C.] Howard Univ, Dept Radiol, Lab Mol Imaging, Washington, DC 20060 USA
摘要We demonstrated that three different types of water-soluble fullerenes materials can intercept all of the major physiologically relevant ROS. C(60)(C(COOH)(2))(2), C(60)(OH)(22), and Gd@C(82)(OH)(22) can protect cells against H(2)O(2)-induced oxidative damage, stabilize the mitochondrial membrane potential and reduce intracellular ROS production with the following relative potencies: Gd@C(82)(OH)(22)>= C(60)(OH)(22)> C(60)(C(COOH)(2))(2). Consistent with their cytoprotective abilities, these derivatives can scavenge the stable 2,2-diplienyl-1-picryhydrazl radical (DPPH), and the reactive oxygen species (ROS) superoxide radical anion (O(2)(center dot-)). singlet oxygen, and hydroxyl radical (HO(center dot)), and can also efficiently inhibit lipid peroxidation in vitro. The observed differences in free radical-scavenging capabilities Support the hypothesis that both chemical Properties, such as Surface chemistry induced differences in electron affinity, and physical properties, such as degree of aggregation, influence the biological and biomedical activities of functionalized fullerenes. This represents the first report that different types of fullerene derivatives can scavenge all physiologically relevant ROS. The role of oxidative stress and damage in the etiology and Progression of many diseases suggests that these fullerene derivatives may be valuable in vivo cytoprotective and therapeutic agents. (C) 2008 Elsevier Ltd. All rights reserved.
文章类型Article
关键词Gadolinium endohedral metallofullerenol Fullerenol Carboxyfullerene Scavenging activity Cytoprotection Reactive oxygen species
学科领域Engineering; Materials Science
DOI10.1016/j.biomaterials.2008.09.061
研究领域[WOS]Engineering ; Materials Science
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语种英语
WOS类目Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号WOS:000262065500023
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被引频次:220[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/238103
专题多学科研究中心
加速器中心
作者单位中国科学院高能物理研究所
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Yin, JJ,Lao, F,Fu, PP,et al. The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials[J]. BIOMATERIALS,2009,30(4):611-621.
APA Yin, JJ.,Lao, F.,Fu, PP.,Wamer, WG.,Zhao, YL.,...&陈春英.(2009).The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials.BIOMATERIALS,30(4),611-621.
MLA Yin, JJ,et al."The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials".BIOMATERIALS 30.4(2009):611-621.
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