Synthesis and in vivo study of metallofullerene based MRI contrast agent
Zhang J(张钧); Xing GM(邢更妹); Ren TX(任同祥); Zhang, J; Liu, KM; Xing, GM; Ren, TX; Wang, SK
刊名JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
2007
卷号272期号:3页码:605-609
学科分类Chemistry; Nuclear Science & Technology
DOI10.1007/s10967-007-0632-0
通讯作者Beijing Inst Technol, Sch Life Sci & Technol, Beijing 100081, Peoples R China ; Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100049, Peoples R China
文章类型Article
英文摘要Gd@C-82(OH)(40) has been developed as a new generation of MRI contrast agent. But recently, it was found that Gd@C-82(OH) (x) with a larger number of OH (x > 36) would lead to cage break and hence, release of highly toxic Gd ions. We synthesized the more stable Gd@C-82(OH) (x) with less OH-number, Gd@C-82(OH)(16), and studied its proton relaxivity and MRI images. The results indicate that Gd@C-82(OH)(16) also gives high proton relaxivity, even higher than that of (NMG)(2)-Gd-DTPA. The bio-distribution indicated that Gd@C-82(OH)(16) tends to be entrapped in the liver and kidney and remained in tissue for about 2 hours. The results suggest that the more stable metallofullerene derivative Gd@C-82(OH)(16) can be the potential candidate of the new MRI contrast agent.
类目[WOS]Chemistry, Analytical ; Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology
研究领域[WOS]Chemistry ; Nuclear Science & Technology
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语种英语
WOS记录号WOS:000246184200032
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被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/238089
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_实验物理中心
中国科学院高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
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Zhang J,Xing GM,Ren TX,et al. Synthesis and in vivo study of metallofullerene based MRI contrast agent[J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2007,272(3):605-609.
APA 张钧.,邢更妹.,任同祥.,Zhang, J.,Liu, KM.,...&Wang, SK.(2007).Synthesis and in vivo study of metallofullerene based MRI contrast agent.JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,272(3),605-609.
MLA 张钧,et al."Synthesis and in vivo study of metallofullerene based MRI contrast agent".JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 272.3(2007):605-609.
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