Copper ions influence the toxicity of beta-amyloid(1-42) in a concentration-dependent manner in a Caenorhabditis elegans model of Alzheimer's disease
Luo, YF; Zhang, J; Liu NQ(刘年庆); Liu, NQ; Luo, Y; Zhao, BL
刊名SCIENCE CHINA-LIFE SCIENCES
2011
卷号54期号:6页码:527-534
关键词Alzheimer's disease beta-amyloid(1-42) copper C. elegans oxidative stress
学科分类Life Sciences & Biomedicine - Other Topics
DOI10.1007/s11427-011-4180-z
通讯作者[Luo YunFeng ; Zhao BaoLu] Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China ; [Luo YunFeng] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China ; [Zhang Jie] Rutgers State Univ, Dept Cell Biol, Piscataway, NJ 08854 USA ; [Liu NianQing] Chinese Acad Sci, Inst High Energy Phys, Synchrotron Radiat Lab, Beijing 100049, Peoples R China ; [Luo Yuan] Univ Maryland, Dept Pharmaceut Sci, Baltimore, MD 21201 USA
文章类型Article
英文摘要beta-amyloid (A beta) and copper play important roles in the pathogenesis of Alzheimer's disease (AD). However, the behavioral correlativity and molecular mechanisms of A beta and copper toxicity have been investigated less often. In the present study, we investigated the interaction and toxicity of A beta 1-42 and copper in the A beta 1-42 transgenic Caenorhabditis elegans worm model CL2006. Our data show that the paralysis behavior of CL2006 worms significantly deteriorated after exposure to 10(-3) mol L(-1) copper ions. However, the paralysis behavior was dramatically attenuated with exposure to 10(-4) mol L(-1) copper ions. The exogenous copper treatment also partially changed the homeostatic balance of zinc, manganese, and iron. Our data suggest that the accumulation of reactive oxygen species (ROS) was responsible for the paralysis induced by A beta and copper in CL2006. The ROS generation induced by A beta and copper appear to be through sod-1, prdx-2, skn-1, hsp-60 and hsp-16.2 genes.
类目[WOS]Biology
研究领域[WOS]Life Sciences & Biomedicine - Other Topics
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语种英语
WOS记录号WOS:000292050500005
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被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/237832
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
作者单位中国科学院高能物理研究所
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Luo, YF,Zhang, J,Liu NQ,et al. Copper ions influence the toxicity of beta-amyloid(1-42) in a concentration-dependent manner in a Caenorhabditis elegans model of Alzheimer's disease[J]. SCIENCE CHINA-LIFE SCIENCES,2011,54(6):527-534.
APA Luo, YF,Zhang, J,刘年庆,Liu, NQ,Luo, Y,&Zhao, BL.(2011).Copper ions influence the toxicity of beta-amyloid(1-42) in a concentration-dependent manner in a Caenorhabditis elegans model of Alzheimer's disease.SCIENCE CHINA-LIFE SCIENCES,54(6),527-534.
MLA Luo, YF,et al."Copper ions influence the toxicity of beta-amyloid(1-42) in a concentration-dependent manner in a Caenorhabditis elegans model of Alzheimer's disease".SCIENCE CHINA-LIFE SCIENCES 54.6(2011):527-534.
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