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Subcellular distribution of Al, Cu, Mg, Mn and other elements in the human liver
Chen CY(陈春英); Zhang PQ(章佩群); Lu XL(卢向丽); Hou XL(侯小琳); Chai ZF(柴之芳); Chen, CY; Zhang, PQ; Lu, XL; Hou, XL; Chai, ZF
刊名FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY
1999
卷号363期号:5-6页码:512-516
学科分类Chemistry
DOI10.1007/s002160051235
通讯作者Chinese Acad Sci, Inst High Energy Phys, Beijing 100080, Peoples R China ; Chinese Acad Sci, Lab Nucl Anal Tech, Beijing 100080, Peoples R China
文章类型Article; Proceedings Paper
英文摘要The elemental concentrations and chemical species of Al, Br, Cl, Cu, K, Mg, Mn, Na and I in human liver and its subcellular fractions were studied by several biochemical techniques combined with neutron activation analysis. The highest concentrations of Al, Mg, and I were found in the nuclei, whereas those of Br, Cu, Cl, K;, Mn and Na in the cytosol. About 20% of Br, half of Al and most of Cu (78.8%), Mg (65.9%) and Mn (80.6%) remained in the cellulose bags after dialysis of liver homogenate, which were suggested to be bound to macromolecules. K (100%) and more than 95% of CI and Na were found to be in the dialyzates. Similar results were found in the fractions of nuclei, mitochondria, lysosome and microsome, respectively, after the same treatment. Further study was carried out to elucidate the elemental distribution in the cytosol by ethanol precipitation and by ammonium sulfate fractionation. The results suggested that several kinds of Cu-, Mn- and Mg-bound proteins existed in the cytosol of human liver cells.
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
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语种英语
WOS记录号WOS:000079187700020
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被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/237772
专题院士_期刊论文
作者单位中国科学院高能物理研究所
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Chen CY,Zhang PQ,Lu XL,et al. Subcellular distribution of Al, Cu, Mg, Mn and other elements in the human liver[J]. FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY,1999,363(5-6):512-516.
APA 陈春英.,章佩群.,卢向丽.,侯小琳.,柴之芳.,...&Chai, ZF.(1999).Subcellular distribution of Al, Cu, Mg, Mn and other elements in the human liver.FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY,363(5-6),512-516.
MLA 陈春英,et al."Subcellular distribution of Al, Cu, Mg, Mn and other elements in the human liver".FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY 363.5-6(1999):512-516.
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