Delayed changes in T-1-weighted signal intensity in a rat model of 15-minute transient focal ischemia studied by magnetic resonance imaging/spectroscopy and synchrotron radiation X-ray fluorescence
Wang, XX; Qian, JC; He, R; Wei, L; Liu, NQ; Zhang, ZY; Huang, YY; Lei, H; Liu NQ(刘年庆); Zhang ZY(张智勇)
刊名MAGNETIC RESONANCE IN MEDICINE
2006
卷号56期号:3页码:474-480
关键词magnetic resonance synchrotron radiation X-ray fluorescence brain transient focal ischemia rat
学科分类Radiology, Nuclear Medicine & Medical Imaging
DOI10.1002/mrm.20985
通讯作者Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China ; Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China ; Chinese Acad Sci, Inst High Energy Phys, Lab Nucl Analyt Techn, Beijing 100080, Peoples R China ; Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Lab, Beijing 100080, Peoples R China
文章类型Article
英文摘要Previous studies have found that rats subjected to 15-min transient middle cerebral artery occlusion (MCAO) show neurodegeneration in the dorsolateral striatum only, and the resulting striatal lesion is associated with increased T-1-weighted (T1W) signal intensity (SI) and decreased T-2-weighted (T2W SI at 2-8 weeks after the initial ischemia. It has been shown that the delayed increase in T1W SI in the ischemic region is associated with deposition of paramagnetic manganese ions. However, it has been suggested that other mechanisms, such as tissue calcification and lipid accumulation, also contribute to the relaxation time changes. To clarify this issue, we measured changes in relaxation times, lipid accumulation, and elemental distributions in the brain of rats subjected to 15-min MCAO using MRI, in vivo H-1 MR spectroscopy (MRS), and synchrotron radiation X-ray fluorescence (SRXRF). The results show that a delayed (2 weeks after ischemia) increase in T1W SI in the ischemic striatum is associated with significant increases in manganese, calcium, and iron, but without evident accumulation of MRS-visible lipids or hydroxyapatite precipitation. It was also found that 15-min MCAO results in acutely reduced N-acetylaspartate (NAA)/creatine (Cr) ratio in the ipsilateral striatum, which recovers to the control level at 2 weeks after ischemia.
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
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语种英语
WOS记录号WOS:000240245600002
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被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/237632
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
作者单位中国科学院高能物理研究所
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Wang, XX,Qian, JC,He, R,et al. Delayed changes in T-1-weighted signal intensity in a rat model of 15-minute transient focal ischemia studied by magnetic resonance imaging/spectroscopy and synchrotron radiation X-ray fluorescence[J]. MAGNETIC RESONANCE IN MEDICINE,2006,56(3):474-480.
APA Wang, XX.,Qian, JC.,He, R.,Wei, L.,Liu, NQ.,...&张智勇.(2006).Delayed changes in T-1-weighted signal intensity in a rat model of 15-minute transient focal ischemia studied by magnetic resonance imaging/spectroscopy and synchrotron radiation X-ray fluorescence.MAGNETIC RESONANCE IN MEDICINE,56(3),474-480.
MLA Wang, XX,et al."Delayed changes in T-1-weighted signal intensity in a rat model of 15-minute transient focal ischemia studied by magnetic resonance imaging/spectroscopy and synchrotron radiation X-ray fluorescence".MAGNETIC RESONANCE IN MEDICINE 56.3(2006):474-480.
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